5th International Meeting on Quadruplex Nucleic Acids

›8:30 (2h)

Session 5: G4s and Replication or Helicases
Tracy Bryan

8:30 - 10:30 (2h)

Session 5: G4s and Replication or Helicases

Tracy Bryan

› Short loop-length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites - Alain Nicolas, Institut Curie, Paris, France 08:30-08:50 (20min)

› Evidence that G-quadruplex levels increase during S-phase in human cells, and are elevated throughout the cell cycle in Werner and Bloom syndrome cells - F. Brad Johnson, University of Pennsylvania, USA 08:50-09:10 (20min)

› Recognition of unique RNA structures by quadruplex helicases and their functional consequences. - Sean McKenna, University of Manitoba, Canada 09:10-09:30 (20min)

› G4 elements and DNA replication origins: a genome-wide and functional analysis in metazoans - Paulina Prorok, Institut de Génétique Humaine, CNRS, Montpellier, France 09:30-09:50 (20min)

› G4 motifs are necessary but not sufficient for replication initiation in Vertebrates - Marie-Noëlle Prioleau, Institut Jacques Monod, Université Paris Diderot, Paris, France 09:50-10:10 (20min)

› Propagation of a single unresolved G quadruplex structure in proliferating tissues causes multiple genomic rearrangements and genetic heterogeneity - Marcel Tijsterman, Leiden University Medical Center, Leiden, The Netherlands 10:10-10:30 (20min)

›10:30 (30min)

Coffee break

10:30 - 11:00 (30min)

Coffee break

›11:00 (1h20)

Session 6: Novel G4-based Assemblies
Anh Tuan Phan

11:00 - 12:20 (1h20)

Session 6: Novel G4-based Assemblies

Anh Tuan Phan

› Encapsulation and Delivery of Therapeutic Agents by Nanoparticles Formed Supramolecular G-quadruplexes - Jose Rivera, University of Puerto Rico, Río Piedras, Puerto Rico 11:00-11:20 (20min)

› Intramolecular, Multimeric and Supramolecular G-quadruplex Assemblies - Viktor Viglasky, Pavol Jozef Safarik University, Kosice, Slovakia 11:20-11:40 (20min)

› Stabilising i-motif DNA structures with cations and ligands - Zoe Waller, UEA School of Pharmacy, Norwich, UK 11:40-12:00 (20min)

› The Quest for Charge Transport in single Adsorbed Long DNA-Based Molecules - Danny Porath, Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, 91904 12:00-12:20 (20min)

›12:20 (50min)

Poster flash presentations: Session II
Thomas C. Marsh

12:20 - 13:10 (50min)

Poster flash presentations: Session II

Thomas C. Marsh

› DNA G-quadruplex formation: a new pathway - Primoz Sket, EN-FIST Centre of Excellence, Slovenian NMR Centre, National Institute of Chemistry, Ljubljana, Slovenia 12:20-12:25 (05min)

› Thermodynamics and kinetics study of individual K+ binding events reveal new aspects of DNA G-quadruplex folding pathways - Adrien Marchand, Inserm U869 ARNA, IECB, Bordeaux, France 12:25-12:30 (05min)

› Electronic Properties of Guanine Assemblies in G-quadruplex Nucleic Acids - Christopher Lech, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 12:30-12:35 (05min)

› G-quartets and Supramolecular Structures of Guanosine-5'-monophosphates: Effect of the Ribose versus 2'-deoxyribose Residue - Katerina Mudronova, Faculty of Mathematics and Physics, Praha/Prague, Czech Republic 12:35-12:40 (05min)

› G-quadruplex DNAzyme-modified Nucleotides for diagnostic applications - Daniela Verga, University of Konstanz, Germany 12:40-12:45 (05min)

› Higher-Order Human Telomeric G-Quadruplex DNA Metalloenzymes Enhance Enantioselectivity in the Diels–Alder Reaction - Yinghao Li, University of Chinese Academy of Sciences, State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, P.R. China 12:45-12:50 (05min)

› G4-hunter, a novel algorithm to predict G-quadruplex folding propensity through score computing - Amina Bedrat, U869, Laboratoire ARNA, IECB, Bordeaux, France 12:50-12:55 (05min)

› Interaction of mutant p53 proteins with DNA quadruplexes in vitro and in cells - Marie Brázdová, Institute of Biophysics of the AS CR, v.v.i., Brno, Czech Republic 12:55-13:00 (05min)

› Role of Nucleotide Excision Repair and Topoisomerase II proteins on pyridostatin-induced double-stranded DNA breaks - Charlotte Dunet, Institut de pharmacologie et de biologie structurale, CNRS, Toulouse, France 13:00-13:05 (05min)

› G4s and RecQ helicases in the human malaria parasite Plasmodium falciparum - Lynne Harris, Keele University, UK 13:05-13:10 (05min)

›13:10 (2h30)

Lunch - Poster session II: Wed-P01 to Wed-P10 are posters that had a flash presentation, Wed-P11 to Wed-P52 are posters only

13:10 - 15:40 (2h30)

Lunch - Poster session II: Wed-P01 to Wed-P10 are posters that had a flash presentation, Wed-P11 to Wed-P52 are posters only

›13:10 (2h30)

Posters (no flash): Session II

13:10 - 15:40 (2h30)

Posters (no flash): Session II

› A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands. - Anne Bourdoncle, ARNA Laboratory, Bordeaux, France 13:10-15:40 (2h30)

› A Naphthalene Diimide Dyad as Selective Light Up Probe for G-quadruplex Sensing - Filippo Doria, Department of Chemistry, University of Pavia 13:10-15:40 (2h30)

› Design and synthesis of a berberine dimer as a fluorescent ligand with high affinity toward G-quadruplex - Masayuki Tera, Suntory Foundation for Life Science, Osaka, Japan 13:10-15:40 (2h30)

› Effect of low molecular weight ligands on the structural stability of G-quadruplexes - Petra Krafčíková, University of P.J. Safarik, Košice, Slovak Republic 13:10-15:40 (2h30)

› Extended core naphtalene diimides as G-quadruplex sensors and improved anticancer compounds - Matteo Nadai, Department of Molecular Medicine, University of Padua 13:10-15:40 (2h30)

› FRET-melting studies to assess the selectivity of G4 ligands - Aurore De Rache, ARNA Laboratory, IECB Bordeaux, France 13:10-15:40 (2h30)

› G-quadruplex structure alteration induced by cations in relation to DNAzyme peroxidase activity - Joanna Kosman, Laboratory of Bioanalytical Chemistry, Faculty of Chemistry, Adam Mickiewicz University 13:10-15:40 (2h30)

› Indolylmethyleneindanone based molecules specifically stabilize promoter quadruplex DNAs over telomeric and duplex DNAs - Divesh Kumar K V, Indian Institute of Technology [Bombay] - PRADEEPKUMAR P.I., PRADEEPKUMAR P.I. 13:10-15:40 (2h30)

› Interactions of two pentanuclear lanthanide (III) metallacrowns with human telomeric DNA - Ewa Rajczak, Adam Mickiewicz University, Faculty of Chemistry, Poland 13:10-15:40 (2h30)

› Investigation of the effect of G-quadruplex ligand on the expression and splicing of VEGF mRNA - Taiki Saito, Graduate school of Engineering, Tokyo University of Agriculture and Technology 13:10-15:40 (2h30)

› Light induced conformational changes of the telomeric G4 DNA in complex with Zn(II) tetracarboxymethyl porphyrin - Artemy Beniaminov, Engelhardt Institute of Molecular Biology RAS, Moscow, Russia 13:10-15:40 (2h30)

› Small Molecule Destabilisation of Intermolecular G-Quadruplexes - Louis Chan, Department of Chemistry (Cambridge, UK) 13:10-15:40 (2h30)

› Targeting DNA quadruplexes with aromatic oligoamide foldamers - Simon Dawson, Chimie et Biologie des Membranes et des Nanoobjets 13:10-15:40 (2h30)

› Terpyridine-platinum complexes derivatives as probes for telomere targeting - Sophie Bombard, INSERM UMR-S 1007, Université Paris Descartes; 13:10-15:40 (2h30)

› Base Lesions in the G-tetrads and the Loops Have Varying Effects on the Folding and Stability of the Human Telomere G-quadruplex - Helena Konvalinová, Department of Biochemistry, Faculty of Science, Masaryk University 13:15-15:40 (2h25)

› Divalent cations prefold a telomeric G-Quadruplex sequence into a nascent, parallel structural form - Patrick Groves, University of Gdansk, Instituto de Tecnologia Química e Biológica 13:15-15:40 (2h25)

› Effective incorporation of modified nucleotides into G-quadruplex nucleic acids - Brahim Heddi, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 13:15-15:40 (2h25)

› Gene regulation by RNA G-quadruplexes. New insights into the G-quadruplex structure at the 5'UTR of the BCL2 mRNA human proto-oncogene - Alicia Dominguez-Martin, University of Zürich 13:15-15:40 (2h25)

› Insights from 10 µs-scale molecular dynamics simulations of human telomeric quadruplex - Barira Islam, Central European Institute of Technology, Masaryk University 13:15-15:40 (2h25)

› Interaction between guanosine and a G-quadruplex with a vacant site - Si Ming Pang, School of Physical and Mathematical Sciences, NTU 13:15-15:40 (2h25)

› Investigating divalent cation binding to folded G-Quadruplexes - Malgorzata Palczewska, Department of Biomedical Chemistry, University of Gdansk, POLAND 13:15-15:40 (2h25)

› Joining of Multiple Duplex Stems at a Single Quadruplex Loop - Kah Wai Lim, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 13:15-15:40 (2h25)

› Probing the folding dynamics of human telomeric G-quadruplex with single-molecule FRET - Mikayel Aznauryan, Centre for DNA Nanotechnology (CDNA), Aarhus University, Interdisciplinary Nanoscience Center (iNANO), Aarhus University 13:15-15:40 (2h25)

› Structure, stability and cooperativity in guanine quadruplexes - Celia Fonseca Guerra, VU University Amsterdam 13:15-15:40 (2h25)

› Fine-tuning of the DNA i-motif stability: lesson learnt from epigenetic regulation of telomeric DNA from plants - Silvie Trantirkova, Central European Institute of Technology - Masaryk University 13:20-15:40 (2h20)

› Hairpin or i-Motif? - Elise Wright, UEA School of Pharmacy, Norwich, UK 13:20-15:40 (2h20)

› Spectral characterization of i-motif enclosed in a hairpin loop for intracellular pH measurements - Anna Dembska, Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland 13:20-15:40 (2h20)

› Study of the solution equilibria of two i-motif- and G-quadruplex-forming sequences found at the SMARCA4 gen - Sanae Benabou, Universitat de Barcelona 13:20-15:40 (2h20)

› Discovery of a New Fluorescent Light-Up Probe Specific to Parallel G-Quadruplexes - Shuo-Bin Chen, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 13:25-15:40 (2h15)

› Duplex stem-loop-containing quadruplex motifs in the human genome: A combined genomic and structural study - Vladimir Kuznetsov, Bioinformatics Institute/A*STAR 13:25-15:40 (2h15)

› Evolutionarily conserved properties of telomeric DNA - Lukas Trantirek, Central European Institute of Technology - Masaryk University 13:25-15:40 (2h15)

› Importance of G4 structure for the activity of metazoan origins of DNA replication - Paulina Prorok, Institut de génétique humaine - Marcel Méchali, Institut de génétique humaine 13:25-15:40 (2h15)

› Short loop length and high thermal stability determine genomic instability induced by G-quadruplex forming minisatellites - Frédéric SAMAZAN, Dynamique de l'information génétique : bases fondamentales et cancer 13:25-15:40 (2h15)

› A dual functional G4-DNAzyme for cells antiproliferation mediated by nucleolin targeting and hydrogen peroxide trigger - Yan Yang, Dalian Institute of Chemical Physics 13:30-15:40 (2h10)

› Molecular Diagnostics Based on Quadruplex Priming Amplification and Nicking Enzyme Activity - Shota Gogichaishvili, Andronikashvili Institute of Physics, TSU, Tbilisi 0177, Republic of Georgia 13:30-15:40 (2h10)

› Thermodynamic and Optical properties of Quadruplex Primers for Isothermal DNA Amplification - David Gvarjaladze, Institute of Biophysics, Ilia State University, Tbilisi 0162, Republic of Georgia 13:35-15:40 (2h05)

› Braf promoter undergoes to “non-canonical”rearrangements under nearly physiological conditions - Maria Laura Greco, Dept. of Pharmaceutical and Pharmacological Sciences, via Marzolo 5,35131, Padova, Italy 13:40-15:40 (2h)

› Comparing p63 to other p53 family members on binding to G4 - Matej Adámik, Institute of Biophysics of the AS CR, v.v.i., Brno, CR 13:40-15:40 (2h)

› G-rich sequences within proto-oncogene KIT promoter region as targets for anticancer therapy - claudia sissi, Department of Pharmaceutical and Pharmacological Sciences, University of Padova 13:40-15:40 (2h)

› Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation - Stefania Millevoi, Cancer Research Center of Toulouse (CRCT) 13:40-15:40 (2h)

› The Amyloid Precursor Protein is Negatively Regulated by a 3'UTR G-quadruplex - Ezekiel Crenshaw, Drexel University 13:40-15:40 (2h)

› Investigation of G-quadruplex-ligand interactions using NMR spectroscopy - Julia Wirmer-Bartoschek, J.W. Goethe Universität Frankfurt, Max von Laue Str. 7, 60439 Frankfurt 13:45-15:40 (1h55)

›15:40 (2h20)

Session 7: G4 Ligands part 2
Dipankar Sen

15:40 - 18:00 (2h20)

Session 7: G4 Ligands part 2

Dipankar Sen

› Fine-tuning molecular tools for probing the G4 genome - Marie-Paule Teulade-Fichou, Institut Curie, Orsay, France 15:40-16:00 (20min)

› Topologies selective small molecules for telemetric G-quadruplex - Kazuo Nagasawa, Tokyo University of Agriculture and Technology, Japan 16:00-16:20 (20min)

› Fluorescent anti-tumor agents (FATAs) induced cancer cell death via the interaction of mitochondrial G-quadruplex DNA - Ta-Chau Chang, Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan 16:20-16:40 (20min)

› Topology Specific Stabilization of Promoter over Telomeric G-Quadruplex DNAs by Designer Molecules - Pradeepkumar P.I., Indian Institute of Technology Bombay, Mumbai, India 16:40-17:00 (20min)

› Photochemistry Gives the Green Light to Tel22 Thymine Targeting - Mauro Freccero, University of Pavia, Italy 17:00-17:20 (20min)

› Quadruplex targeting and imaging: “stay on TASQ!” - David Monchaud, Institut de Chimie Moléculaire de l'Université de Bourgogne, Dijon, France 17:20-17:40 (20min)

› Epigenetic reprogramming with G-quadruplex ligands - Guillaume Guilbaud, MRC Laboratory of Molecular Biology, Cambridge, UK 17:40-18:00 (20min)

›19:45 (2h45)

Gala Dinner

19:45 - 22:30 (2h45)

Gala Dinner