5th International Meeting on Quadruplex Nucleic Acids: G4thering in Bordeaux

Chemistry, Biology and Nanotechnology

26-28 May 2015 Bordeaux (France)

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Scientific Program

Week Tue. 26 Wed. 27 Thu. 28 List

Tuesday, May 26, 2015 ›

08:00

09:00

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11:00

12:00

13:00

14:00

15:00

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20:00

21:00

›8:00 (1h)

Arrival and registration

8:00 - 9:00 (1h)

Arrival and registration

Collecting badges and conference materials at the reception desk

›9:00 (10min)

Opening address
Jean-Louis Mergny

9:00 - 9:10 (10min)

Opening address

Jean-Louis Mergny

›9:10 (30min)

Introduction to G-quadruplexes

9:10 - 9:40 (30min)

Introduction to G-quadruplexes

› Fifty shades of G: Quadruplexes come in many forms! - Jean-Louis Mergny, Institut Européen de Chimie et Biologie 09:10-09:40 (30min)

›9:40 (1h20)

Session 1: G4 Folding
Nancy Maizels

9:40 - 11:00 (1h20)

Session 1: G4 Folding

Nancy Maizels

› Promoter and Telomeric Quadruplexes: Size Does Matter - Jonathan Chaires, James Graham Brown Cancer Center, Louisville, KY, USA 09:40-10:00 (20min)

› Thermodynamics of human telomere quadruplex binding-coupled structural alterations - Jurij Lah, University of Ljubljana, Slovenia 10:00-10:20 (20min)

› Advanced computational studies of G-quadruplex folding and topological preferences. - Jiri Sponer, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic 10:20-10:40 (20min)

› Mass spectrometry reveals new aspects of human telomeric G-quadruplex folding pathways in potassium - Valentina D'Atri, U869 ARNA (Inserm/Univ. Bordeaux), Pessac, France 10:40-11:00 (20min)

›11:00 (30min)

Coffee break

11:00 - 11:30 (30min)

Coffee break

›11:30 (1h40)

Session 2: G4 Ligands part 1
Marie-Paule Teulade-Fichou

11:30 - 13:10 (1h40)

Session 2: G4 Ligands part 1

Marie-Paule Teulade-Fichou

› G-quadruplexes and heme: strange partners from SELEX to biology - Dipankar Sen, Simon Fraser University, British Columbia, Canada 11:30-11:50 (20min)

› Heme-DNA Complexes - Yasuhiko Yamamoto, University of Tsukuba, Japan 11:50-12:10 (20min)

› The Story of NMM, my Favorite Quadruplex Ligand - Liliya Yatsunyk, Swarthmore College, USA 12:10-12:30 (20min)

› An Integrated Platform for Quadruplex-Targeted Drug Discovery - John Trent, James Graham Brown Cancer Center, Louisville, KY, USA. 12:30-12:50 (20min)

› The design and development of G4-binding small molecules targeting pancreatic cancer - Stephen Neidle, School of Pharmacy, UCL, London, UK 12:50-13:10 (20min)

›13:10 (1h20)

Lunch

13:10 - 14:30 (1h20)

Lunch

›14:30 (1h20)

Session 3: G4s in Cancer
Lukas Trantirek

14:30 - 15:50 (1h20)

Session 3: G4s in Cancer

Lukas Trantirek

› Common hTERT Promoter Quadruplex-disrupting Mutations Provide a Target for Melanoma Therapy - Donald Miller, Brown Cancer Center, University of Louisville, KY, USA 14:30-14:50 (20min)

› TERRA G-quadruplex as a potential modifier of the genome-wide gene expression and cancer behavior in vivo - Hiroyuki Seimiya, Japanese Foundation for Cancer Research, Tokyo, Japan 14:50-15:10 (20min)

› G-Quadruplexes and Gold: A Winning Combination Against Cancer? - Paula Bates, University of Louisville, KY, USA 15:10-15:30 (20min)

› Involvement of G-quadruplexes in the Alternative Lengthening of Telomere (ALT) mechanism in human cancer cells - Tracy Bryan, Children's Medical Research Institute, University of Sydney, Australia 15:30-15:50 (20min)

›15:50 (30min)

Coffee break

15:50 - 16:20 (30min)

Coffee break

›16:20 (1h)

Session 4: Novel G4 Structures
Antonio Randazzo

16:20 - 17:20 (1h)

Session 4: Novel G4 Structures

Antonio Randazzo

› Folding intermediates and fascinating new structures - Janez Plavec, Slovenian NMR centre, Ljubljana, Slovenia 16:20-16:40 (20min)

› Telomeric Quadruplex/Duplex Interfaces: A Target for Drug Design - Gary Parkinson, University College London, School of Pharmacy, London, UK 16:40-17:00 (20min)

› Structure, engineering, and recognition of G-quadruplexes - Anh Tuan Phan, Nanyang Technological University, Singapore 17:00-17:20 (20min)

›17:20 (50min)

Poster flash presentations: Session I
Liliya Yatsunyk

17:20 - 18:10 (50min)

Poster flash presentations: Session I

Liliya Yatsunyk

› Racemic DNA Crystallography helps to determine G4 structures - Pradeep MANDAL, Chimie et Biologie des Membranes et des Nanoobjets, Institut Européen de Chimie et Biologie, Bordeaux, France 17:20-17:25 (05min)

› Editing Tetrad Polarities in Unimolecular G-Quadruplexes - Jonathan Dickerhoff, Ernst-Moritz-Arndt University Greifswald, Institute of Biochemistry, Germany 17:25-17:30 (05min)

› G-quadruplex with DNA base lesions: Xanthine and 8-oxoguanine - Vee Vee Cheong, Nanyang Technological University, Singapore 17:30-17:35 (05min)

› Dictyostelium, a new model to quadruplex studies - Souheila Amor, ARNA laboratory, Bordeaux, France 17:35-17:40 (05min)

› Unlocking the therapeutic potential of 5'UTR RNA G-quadruplexes with Peptide Nucleic Acid (PNA)-small molecule conjugates - Douglas Vair-Turnbull, Imperial College London, UK 17:40-17:45 (05min)

› Targeted Detection of G-Quadruplexes in Cellular RNAs - chun kit kwok, Department of Chemistry (Cambridge, UK), Cancer Research UK Cambridge Institute 17:45-17:50 (05min)

› A Novel Antibody Determines the Parallel G-quadruplex Sequence Consensus and Preferential Telomeric G4 Conformation in Human Cell - Huiyun Liu, School of Pharmaceutical Sciences, Sun Yat-sen University, P.R. China 17:50-17:55 (05min)

› Guanine oxidation in the G4-containing sequence of KRAS is an oxidative lesion or an epigenetic transcription marker? - Marco Quercia, Department of Medical and Biological Sciences, University of Udine, Italy 17:55-18:00 (05min)

› A G-quadruplex forming aptamer potently inhibits HIV-1 entry into the host cell - Martina Tassinari, Department of Molecular Medicine, University of Padua, Italy 18:00-18:05 (05min)

› G-Quadruplexes and MicroRNAs: a Dynamic Duo - Samuel Rouleau, Université de Sherbrooke, Canada 18:05-18:10 (05min)

›18:10 (2h50)

Wine & Cheese party - Poster session I: Tue-P01 to Tue-P10 are posters that had a flash presentation, Tue-P11 to Tue-P52 are posters only

18:10 - 21:00 (2h50)

Wine & Cheese party - Poster session I: Tue-P01 to Tue-P10 are posters that had a flash presentation, Tue-P11 to Tue-P52 are posters only

›18:10 (2h50)

Posters (no flash): Session I

18:10 - 21:00 (2h50)

Posters (no flash): Session I

› Binding Studies of N5-Methylated Indolo[3,2-b]quinoline Derivatives to G-Quadruplexes of Different Topology - Andrea Funke 18:10-21:00 (2h50)

› Characterization of interactions between Pt-ttpy and G-quadruplexes originating from promoter region of c-myc gene - Marko Trajkovski, National Institute of Chemistry Slovenia 18:10-21:00 (2h50)

› Dissection of energetics of ligand binding to the human telomere 3' sequence of d(AGGG(TTAGGG)3) - Matjaz Boncina, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Vecna pot 113, 1000 Ljubljana 18:10-21:00 (2h50)

› Dynamics of Cy3-analogues attached to a G-quadruplex - interpreting FRET through MD simulations - Siri Søndergaard, Aarhus University [Aarhus] 18:10-21:00 (2h50)

› G4-OAS in action: Discovery and evaluation of novel G4-binders - Daniela Montesarchio, Department of Chemical Sciences, University of Naples Federico II 18:10-21:00 (2h50)

› Helquats: novel class of G-quadruplex ligands - Jaroslav Kozák, Institute of Organic Chemistry and Biochemistry, v.v.i., AS CR, Czech Republic 18:10-21:00 (2h50)

› How different sugar presentation in G-quadruplex ligands affect binding affinity and selectivity to G-quadruplex - Matilde Arevalo-Ruiz, Instituto de Parasitologia y Biomedicina 18:10-21:00 (2h50)

› Interaction of G-quadruplex derived from NHE III1 region of c-MYC oncogene (Pu22) with small carbazole ligands - Martyna Kuta, Faculty of Chemistry, Adam Mickiewicz University (POLAND) - Agata Głuszyńska, Faculty of Chemistry, Adam Mickiewicz University (POLAND) 18:10-21:00 (2h50)

› Investigation on the interaction between a Gold(I)-caffeine complex and human telomeric DNA - Francesco Papi, university of florence 18:10-21:00 (2h50)

› Ligand Induced Conformational Preorganization of Loops and Grooves of c-MYC G-Quadruplex DNA and its Implications in Structure Specific Drug Design - S Harikrishna, Indian Institute of Technology [Bombay] 18:10-21:00 (2h50)

› Localizing K+ and ligands in G-quadruplexes using a new MS/MS fragmentation technique: electron photodetachment dissociation (EPD) - Dababrata Paul, INSERM U869, ARNA laboratory Bordeaux F-33000, France, Univ. Bordeaux IECB, ARNA laboratory Pessac F-33600, France 18:10-21:00 (2h50)

› Recognition Agents for Nucleic Acid Quadruplex Structures in Cells - Lois Bright, University of Birmingham 18:10-21:00 (2h50)

› Synthesis of G-quadruplex ligands by dual interaction strategy and evaluation of their stabilization ability - YUE MA, Tokyo University of Agriculture and Technology 18:10-21:00 (2h50)

› Testing G4 ligand activity using an in vitro translation system - HONG ANH TRUONG, Nanyang Technological University 18:10-21:00 (2h50)

› Ultrafast electron transfer in complexes of Doxorubicin with human telomeric G-quadruplexes probed by femtosecond fluorescence spectroscopy - Pascale Changenet-Barret, Laboratoire d'Optique et Biosciences, Palaiseau, France 18:10-21:00 (2h50)

› A G-rich sequence adopts a tetrahelical DNA fold different from G-quadruplexes - Vojc Kocman, Slovenian NMR Centre, National Institute of Chemistry 18:15-21:00 (2h45)

› A Rational Approach to Constructing DNA G-Quadruplexes - Scarlett Dvorkin, University of Ulster 18:15-21:00 (2h45)

› Concentration-Dependent Behaviour of H-Tel and 19 Related ODNs - Rob Macgregor, Department of Pharmaceutical Sciences, U. Toronto 18:15-21:00 (2h45)

› Formation of G-quadruplexes in poly-G sequences: Structure of a propeller-type parallel-stranded G-quadruplex formed by a G15 stretch - Anjali Sengar, Nanyang Technological University 18:15-21:00 (2h45)

› G-quadruplex production and stabilization - Carla Cruz, CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior 18:15-21:00 (2h45)

› Intermediates in Folding of Human Telomeric Quadruplexes Studied by Molecular Dynamics Simulations - Petr Stadlbauer, Institute of Biophysics, Academy of Sciences of the Czech Republic 18:15-21:00 (2h45)

› Solution structure of a DNA quadruplex containing ALS and FTD related GGGGCC repeat stabilized by 8-bromodeoxyguanosine substitution - Jasna Brcic, Slovenian NMR Center, National Institute of Chemistry 18:15-21:00 (2h45)

› Structural properties of G-quadruplex formed in the oncogene RET promoter sequences - Petra Tothova, Department of Biochemistry, Institute of Chemistry, Faculty of Sciences, Pavol Jozef Safarik University 18:15-21:00 (2h45)

› The influence of RNA sequence, concentration, type of cation and cellular environment on the folding of RNA G-quadruplex composed of AGG, CGG and UGG repeats - Magdalena Malgowska, Institute of Bioorganic Chemistry, Poznan, Poland 18:15-21:00 (2h45)

› Unravelling biologically relevant RNA G-quadruplexes: single molecule studies and metal ion dependency - Helena Guiset Miserachs, Department of Chemistry, University of Zürich 18:15-21:00 (2h45)

› Biotechnological applications of Quadruplexes - Besik Kankia, Ilia State University, The Ohio State University 18:20-21:00 (2h40)

› Investigation of G-quadruplexes by fluorescence lifetime imaging microscopy - Ting-Yuan Tseng, Institute of Atomic and Molecular Sciences, Academia Sinica 18:20-21:00 (2h40)

› Characterization of the interaction between cellular proteins and guanine quadruplex motifs located in the 5' UTR of mRNAs - Jens Kurreck, Technische Universität Berlin [Berlin] 18:25-21:00 (2h35)

› G-quadruplex in the promoter region of zinc transporter protein Zip1 - Daniela Franco Bodek, Imperial College London 18:25-21:00 (2h35)

› G-quadruplexes – proteins in charge - Václav Brázda, Institute of Biophysics of the AS CR, v.v.i. 18:25-21:00 (2h35)

› The DNA structure preferences of IFI16 protein - Lucia Hároníková, Department of Biochemistry, Masaryk University, Institute of Biophysics of the AS CR, v.v.i. 18:25-21:00 (2h35)

› Wild-type p53 protein binding to promoter DNA quadruplexes - Marek Petr, Institute of Biophysics of the AS CR, v.v.i. 18:25-21:00 (2h35)

› KRAS ONCOGENE REPRESSION IN COLON CANCER CELL LINES BY G-QUADRUPLEX BINDING INDOLOQUINOLINES - Alexandra Paulo, Research Institute for Medicines, Lisbon, Portugal 18:30-21:00 (2h30)

› Occurrence of potential quadruplex-forming sequences in eukaryotic transposable elements of different age - Matej Lexa, Faculty of Informatics [Masaryk University] 18:30-21:00 (2h30)

› System for in vivo study of DNA quadruplexes inside transposable elements - Viktor Tokan, Department of Plant Developmental Genetics, Institue of Biophysics, Academy of Sciences CR v.v.i. 18:30-21:00 (2h30)

› The G-Quadruplex Translation Regulation of BAG-1; an mRNA Involved in Colorectal Cancer - Rachel Jodoin, Université de Sherbrooke (CANADA) 18:30-21:00 (2h30)

› A cellular protein induces and stabilizes the HIV-1 LTR G-quadruplex conformation, a key regulatory element of viral transcription and new antiviral target - Elena Tosoni, Department of Molecular Medicine, University of Padua - Sara Richter, Department of Molecular Medicine, University of Padua 18:35-21:00 (2h25)

› G-quadruplexes in the HIV-1 promoter - Samir AMRANE, INSERM U869 ARNA, Bordeaux, France 18:35-21:00 (2h25)

› Kinetic studies on 5'-modified d(TGGGAG) endowed with prominent anti-HIV activity by ESI-MS - Valeria Romanucci, Department of Chemical Sciences, University of Napoli ‘Federico II'. 18:35-21:00 (2h25)

› Methodological developments of surface plasmon resonance and application to the study of regulatory mechanisms in HCV and HIV-1. - William Palau, ARNA Laboratory, Bordeaux, France 18:35-21:00 (2h25)

› New monomolecular G4-DNA inhibitors of HIV infection - Anna Varizhuk, Engelhardt Institute of Molecular Biology, SRI of Physical-Chemical Medicine 18:35-21:00 (2h25)

› G-quadruplex aptamers with therapeutic applications - Anna Avinyo, Institute for Advanced Chemistry of Catalonia 18:40-21:00 (2h20)

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