Scientific Program

Week Tue. 26 Wed. 27 Thu. 28 List

	Tue. 26	Wed. 27	Thu. 28
08:00 09:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 18:00 19:00 20:00 21:00 22:00	Arrival and registration 8:00 - 9:00 (1h) Arrival and registration Collecting badges and conference materials at the reception desk Opening address 9:00 - 9:10 (10min) Opening address Jean-Louis Mergny Introduction to G-quadruplexes 9:10 - 9:40 (30min) Introduction to G-quadruplexes › Fifty shades of G: Quadruplexes come in many forms! - Jean-Louis Mergny, Institut Européen de Chimie et Biologie 09:10-09:40 (30min) Session 1: G4 Folding 9:40 - 11:00 (1h20) Session 1: G4 Folding Nancy Maizels › Promoter and Telomeric Quadruplexes: Size Does Matter - Jonathan Chaires, James Graham Brown Cancer Center, Louisville, KY, USA 09:40-10:00 (20min) › Thermodynamics of human telomere quadruplex binding-coupled structural alterations - Jurij Lah, University of Ljubljana, Slovenia 10:00-10:20 (20min) › Advanced computational studies of G-quadruplex folding and topological preferences. - Jiri Sponer, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic 10:20-10:40 (20min) › Mass spectrometry reveals new aspects of human telomeric G-quadruplex folding pathways in potassium - Valentina D'Atri, U869 ARNA (Inserm/Univ. Bordeaux), Pessac, France 10:40-11:00 (20min) Coffee break 11:00 - 11:30 (30min) Coffee break Session 2: G4 Ligands part 1 11:30 - 13:10 (1h40) Session 2: G4 Ligands part 1 Marie-Paule Teulade-Fichou › G-quadruplexes and heme: strange partners from SELEX to biology - Dipankar Sen, Simon Fraser University, British Columbia, Canada 11:30-11:50 (20min) › Heme-DNA Complexes - Yasuhiko Yamamoto, University of Tsukuba, Japan 11:50-12:10 (20min) › The Story of NMM, my Favorite Quadruplex Ligand - Liliya Yatsunyk, Swarthmore College, USA 12:10-12:30 (20min) › An Integrated Platform for Quadruplex-Targeted Drug Discovery - John Trent, James Graham Brown Cancer Center, Louisville, KY, USA. 12:30-12:50 (20min) › The design and development of G4-binding small molecules targeting pancreatic cancer - Stephen Neidle, School of Pharmacy, UCL, London, UK 12:50-13:10 (20min) Lunch 13:10 - 14:30 (1h20) Lunch Session 3: G4s in Cancer 14:30 - 15:50 (1h20) Session 3: G4s in Cancer Lukas Trantirek › Common hTERT Promoter Quadruplex-disrupting Mutations Provide a Target for Melanoma Therapy - Donald Miller, Brown Cancer Center, University of Louisville, KY, USA 14:30-14:50 (20min) › TERRA G-quadruplex as a potential modifier of the genome-wide gene expression and cancer behavior in vivo - Hiroyuki Seimiya, Japanese Foundation for Cancer Research, Tokyo, Japan 14:50-15:10 (20min) › G-Quadruplexes and Gold: A Winning Combination Against Cancer? - Paula Bates, University of Louisville, KY, USA 15:10-15:30 (20min) › Involvement of G-quadruplexes in the Alternative Lengthening of Telomere (ALT) mechanism in human cancer cells - Tracy Bryan, Children's Medical Research Institute, University of Sydney, Australia 15:30-15:50 (20min) Coffee break 15:50 - 16:20 (30min) Coffee break Session 4: Novel G4 Structures 16:20 - 17:20 (1h) Session 4: Novel G4 Structures Antonio Randazzo › Folding intermediates and fascinating new structures - Janez Plavec, Slovenian NMR centre, Ljubljana, Slovenia 16:20-16:40 (20min) › Telomeric Quadruplex/Duplex Interfaces: A Target for Drug Design - Gary Parkinson, University College London, School of Pharmacy, London, UK 16:40-17:00 (20min) › Structure, engineering, and recognition of G-quadruplexes - Anh Tuan Phan, Nanyang Technological University, Singapore 17:00-17:20 (20min) Poster flash presentations: Session I 17:20 - 18:10 (50min) Poster flash presentations: Session I Liliya Yatsunyk › Racemic DNA Crystallography helps to determine G4 structures - Pradeep MANDAL, Chimie et Biologie des Membranes et des Nanoobjets, Institut Européen de Chimie et Biologie, Bordeaux, France 17:20-17:25 (05min) › Editing Tetrad Polarities in Unimolecular G-Quadruplexes - Jonathan Dickerhoff, Ernst-Moritz-Arndt University Greifswald, Institute of Biochemistry, Germany 17:25-17:30 (05min) › G-quadruplex with DNA base lesions: Xanthine and 8-oxoguanine - Vee Vee Cheong, Nanyang Technological University, Singapore 17:30-17:35 (05min) › Dictyostelium, a new model to quadruplex studies - Souheila Amor, ARNA laboratory, Bordeaux, France 17:35-17:40 (05min) › Unlocking the therapeutic potential of 5'UTR RNA G-quadruplexes with Peptide Nucleic Acid (PNA)-small molecule conjugates - Douglas Vair-Turnbull, Imperial College London, UK 17:40-17:45 (05min) › Targeted Detection of G-Quadruplexes in Cellular RNAs - chun kit kwok, Department of Chemistry (Cambridge, UK), Cancer Research UK Cambridge Institute 17:45-17:50 (05min) › A Novel Antibody Determines the Parallel G-quadruplex Sequence Consensus and Preferential Telomeric G4 Conformation in Human Cell - Huiyun Liu, School of Pharmaceutical Sciences, Sun Yat-sen University, P.R. China 17:50-17:55 (05min) › Guanine oxidation in the G4-containing sequence of KRAS is an oxidative lesion or an epigenetic transcription marker? - Marco Quercia, Department of Medical and Biological Sciences, University of Udine, Italy 17:55-18:00 (05min) › A G-quadruplex forming aptamer potently inhibits HIV-1 entry into the host cell - Martina Tassinari, Department of Molecular Medicine, University of Padua, Italy 18:00-18:05 (05min) › G-Quadruplexes and MicroRNAs: a Dynamic Duo - Samuel Rouleau, Université de Sherbrooke, Canada 18:05-18:10 (05min) Wine & Cheese party - Poster session I: Tue-P01 to Tue-P10 are posters that had a flash presentation, Tue-P11 to Tue-P52 are posters only Posters (no flash): Session I 18:10 - 21:00 (2h50) Wine & Cheese party - Poster session I: Tue-P01 to Tue-P10 are posters that had a flash presentation, Tue-P11 to Tue-P52 are posters only 18:10 - 21:00 (2h50) Posters (no flash): Session I › Binding Studies of N5-Methylated Indolo[3,2-b]quinoline Derivatives to G-Quadruplexes of Different Topology - Andrea Funke 18:10-21:00 (2h50) › Characterization of interactions between Pt-ttpy and G-quadruplexes originating from promoter region of c-myc gene - Marko Trajkovski, National Institute of Chemistry Slovenia 18:10-21:00 (2h50) › Dissection of energetics of ligand binding to the human telomere 3' sequence of d(AGGG(TTAGGG)3) - Matjaz Boncina, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Vecna pot 113, 1000 Ljubljana 18:10-21:00 (2h50) › Dynamics of Cy3-analogues attached to a G-quadruplex - interpreting FRET through MD simulations - Siri Søndergaard, Aarhus University [Aarhus] 18:10-21:00 (2h50) › G4-OAS in action: Discovery and evaluation of novel G4-binders - Daniela Montesarchio, Department of Chemical Sciences, University of Naples Federico II 18:10-21:00 (2h50) › Helquats: novel class of G-quadruplex ligands - Jaroslav Kozák, Institute of Organic Chemistry and Biochemistry, v.v.i., AS CR, Czech Republic 18:10-21:00 (2h50) › How different sugar presentation in G-quadruplex ligands affect binding affinity and selectivity to G-quadruplex - Matilde Arevalo-Ruiz, Instituto de Parasitologia y Biomedicina 18:10-21:00 (2h50) › Interaction of G-quadruplex derived from NHE III1 region of c-MYC oncogene (Pu22) with small carbazole ligands - Martyna Kuta, Faculty of Chemistry, Adam Mickiewicz University (POLAND) - Agata Głuszyńska, Faculty of Chemistry, Adam Mickiewicz University (POLAND) 18:10-21:00 (2h50) › Investigation on the interaction between a Gold(I)-caffeine complex and human telomeric DNA - Francesco Papi, university of florence 18:10-21:00 (2h50) › Ligand Induced Conformational Preorganization of Loops and Grooves of c-MYC G-Quadruplex DNA and its Implications in Structure Specific Drug Design - S Harikrishna, Indian Institute of Technology [Bombay] 18:10-21:00 (2h50) › Localizing K+ and ligands in G-quadruplexes using a new MS/MS fragmentation technique: electron photodetachment dissociation (EPD) - Dababrata Paul, INSERM U869, ARNA laboratory Bordeaux F-33000, France, Univ. Bordeaux IECB, ARNA laboratory Pessac F-33600, France 18:10-21:00 (2h50) › Recognition Agents for Nucleic Acid Quadruplex Structures in Cells - Lois Bright, University of Birmingham 18:10-21:00 (2h50) › Synthesis of G-quadruplex ligands by dual interaction strategy and evaluation of their stabilization ability - YUE MA, Tokyo University of Agriculture and Technology 18:10-21:00 (2h50) › Testing G4 ligand activity using an in vitro translation system - HONG ANH TRUONG, Nanyang Technological University 18:10-21:00 (2h50) › Ultrafast electron transfer in complexes of Doxorubicin with human telomeric G-quadruplexes probed by femtosecond fluorescence spectroscopy - Pascale Changenet-Barret, Laboratoire d'Optique et Biosciences, Palaiseau, France 18:10-21:00 (2h50) › A G-rich sequence adopts a tetrahelical DNA fold different from G-quadruplexes - Vojc Kocman, Slovenian NMR Centre, National Institute of Chemistry 18:15-21:00 (2h45) › A Rational Approach to Constructing DNA G-Quadruplexes - Scarlett Dvorkin, University of Ulster 18:15-21:00 (2h45) › Concentration-Dependent Behaviour of H-Tel and 19 Related ODNs - Rob Macgregor, Department of Pharmaceutical Sciences, U. Toronto 18:15-21:00 (2h45) › Formation of G-quadruplexes in poly-G sequences: Structure of a propeller-type parallel-stranded G-quadruplex formed by a G15 stretch - Anjali Sengar, Nanyang Technological University 18:15-21:00 (2h45) › G-quadruplex production and stabilization - Carla Cruz, CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior 18:15-21:00 (2h45) › Intermediates in Folding of Human Telomeric Quadruplexes Studied by Molecular Dynamics Simulations - Petr Stadlbauer, Institute of Biophysics, Academy of Sciences of the Czech Republic 18:15-21:00 (2h45) › Solution structure of a DNA quadruplex containing ALS and FTD related GGGGCC repeat stabilized by 8-bromodeoxyguanosine substitution - Jasna Brcic, Slovenian NMR Center, National Institute of Chemistry 18:15-21:00 (2h45) › Structural properties of G-quadruplex formed in the oncogene RET promoter sequences - Petra Tothova, Department of Biochemistry, Institute of Chemistry, Faculty of Sciences, Pavol Jozef Safarik University 18:15-21:00 (2h45) › The influence of RNA sequence, concentration, type of cation and cellular environment on the folding of RNA G-quadruplex composed of AGG, CGG and UGG repeats - Magdalena Malgowska, Institute of Bioorganic Chemistry, Poznan, Poland 18:15-21:00 (2h45) › Unravelling biologically relevant RNA G-quadruplexes: single molecule studies and metal ion dependency - Helena Guiset Miserachs, Department of Chemistry, University of Zürich 18:15-21:00 (2h45) › Biotechnological applications of Quadruplexes - Besik Kankia, Ilia State University, The Ohio State University 18:20-21:00 (2h40) › Investigation of G-quadruplexes by fluorescence lifetime imaging microscopy - Ting-Yuan Tseng, Institute of Atomic and Molecular Sciences, Academia Sinica 18:20-21:00 (2h40) › Characterization of the interaction between cellular proteins and guanine quadruplex motifs located in the 5' UTR of mRNAs - Jens Kurreck, Technische Universität Berlin [Berlin] 18:25-21:00 (2h35) › G-quadruplex in the promoter region of zinc transporter protein Zip1 - Daniela Franco Bodek, Imperial College London 18:25-21:00 (2h35) › G-quadruplexes – proteins in charge - Václav Brázda, Institute of Biophysics of the AS CR, v.v.i. 18:25-21:00 (2h35) › The DNA structure preferences of IFI16 protein - Lucia Hároníková, Department of Biochemistry, Masaryk University, Institute of Biophysics of the AS CR, v.v.i. 18:25-21:00 (2h35) › Wild-type p53 protein binding to promoter DNA quadruplexes - Marek Petr, Institute of Biophysics of the AS CR, v.v.i. 18:25-21:00 (2h35) › KRAS ONCOGENE REPRESSION IN COLON CANCER CELL LINES BY G-QUADRUPLEX BINDING INDOLOQUINOLINES - Alexandra Paulo, Research Institute for Medicines, Lisbon, Portugal 18:30-21:00 (2h30) › Occurrence of potential quadruplex-forming sequences in eukaryotic transposable elements of different age - Matej Lexa, Faculty of Informatics [Masaryk University] 18:30-21:00 (2h30) › System for in vivo study of DNA quadruplexes inside transposable elements - Viktor Tokan, Department of Plant Developmental Genetics, Institue of Biophysics, Academy of Sciences CR v.v.i. 18:30-21:00 (2h30) › The G-Quadruplex Translation Regulation of BAG-1; an mRNA Involved in Colorectal Cancer - Rachel Jodoin, Université de Sherbrooke (CANADA) 18:30-21:00 (2h30) › A cellular protein induces and stabilizes the HIV-1 LTR G-quadruplex conformation, a key regulatory element of viral transcription and new antiviral target - Elena Tosoni, Department of Molecular Medicine, University of Padua - Sara Richter, Department of Molecular Medicine, University of Padua 18:35-21:00 (2h25) › G-quadruplexes in the HIV-1 promoter - Samir AMRANE, INSERM U869 ARNA, Bordeaux, France 18:35-21:00 (2h25) › Kinetic studies on 5'-modified d(TGGGAG) endowed with prominent anti-HIV activity by ESI-MS - Valeria Romanucci, Department of Chemical Sciences, University of Napoli ‘Federico II'. 18:35-21:00 (2h25) › Methodological developments of surface plasmon resonance and application to the study of regulatory mechanisms in HCV and HIV-1. - William Palau, ARNA Laboratory, Bordeaux, France 18:35-21:00 (2h25) › New monomolecular G4-DNA inhibitors of HIV infection - Anna Varizhuk, Engelhardt Institute of Molecular Biology, SRI of Physical-Chemical Medicine 18:35-21:00 (2h25) › G-quadruplex aptamers with therapeutic applications - Anna Avinyo, Institute for Advanced Chemistry of Catalonia 18:40-21:00 (2h20)	Session 5: G4s and Replication or Helicases 8:30 - 10:30 (2h) Session 5: G4s and Replication or Helicases Tracy Bryan › Short loop-length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites - Alain Nicolas, Institut Curie, Paris, France 08:30-08:50 (20min) › Evidence that G-quadruplex levels increase during S-phase in human cells, and are elevated throughout the cell cycle in Werner and Bloom syndrome cells - F. Brad Johnson, University of Pennsylvania, USA 08:50-09:10 (20min) › Recognition of unique RNA structures by quadruplex helicases and their functional consequences. - Sean McKenna, University of Manitoba, Canada 09:10-09:30 (20min) › G4 elements and DNA replication origins: a genome-wide and functional analysis in metazoans - Paulina Prorok, Institut de Génétique Humaine, CNRS, Montpellier, France 09:30-09:50 (20min) › G4 motifs are necessary but not sufficient for replication initiation in Vertebrates - Marie-Noëlle Prioleau, Institut Jacques Monod, Université Paris Diderot, Paris, France 09:50-10:10 (20min) › Propagation of a single unresolved G quadruplex structure in proliferating tissues causes multiple genomic rearrangements and genetic heterogeneity - Marcel Tijsterman, Leiden University Medical Center, Leiden, The Netherlands 10:10-10:30 (20min) Coffee break 10:30 - 11:00 (30min) Coffee break Session 6: Novel G4-based Assemblies 11:00 - 12:20 (1h20) Session 6: Novel G4-based Assemblies Anh Tuan Phan › Encapsulation and Delivery of Therapeutic Agents by Nanoparticles Formed Supramolecular G-quadruplexes - Jose Rivera, University of Puerto Rico, Río Piedras, Puerto Rico 11:00-11:20 (20min) › Intramolecular, Multimeric and Supramolecular G-quadruplex Assemblies - Viktor Viglasky, Pavol Jozef Safarik University, Kosice, Slovakia 11:20-11:40 (20min) › Stabilising i-motif DNA structures with cations and ligands - Zoe Waller, UEA School of Pharmacy, Norwich, UK 11:40-12:00 (20min) › The Quest for Charge Transport in single Adsorbed Long DNA-Based Molecules - Danny Porath, Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, 91904 12:00-12:20 (20min) Poster flash presentations: Session II 12:20 - 13:10 (50min) Poster flash presentations: Session II Thomas C. Marsh › DNA G-quadruplex formation: a new pathway - Primoz Sket, EN-FIST Centre of Excellence, Slovenian NMR Centre, National Institute of Chemistry, Ljubljana, Slovenia 12:20-12:25 (05min) › Thermodynamics and kinetics study of individual K+ binding events reveal new aspects of DNA G-quadruplex folding pathways - Adrien Marchand, Inserm U869 ARNA, IECB, Bordeaux, France 12:25-12:30 (05min) › Electronic Properties of Guanine Assemblies in G-quadruplex Nucleic Acids - Christopher Lech, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 12:30-12:35 (05min) › G-quartets and Supramolecular Structures of Guanosine-5'-monophosphates: Effect of the Ribose versus 2'-deoxyribose Residue - Katerina Mudronova, Faculty of Mathematics and Physics, Praha/Prague, Czech Republic 12:35-12:40 (05min) › G-quadruplex DNAzyme-modified Nucleotides for diagnostic applications - Daniela Verga, University of Konstanz, Germany 12:40-12:45 (05min) › Higher-Order Human Telomeric G-Quadruplex DNA Metalloenzymes Enhance Enantioselectivity in the Diels–Alder Reaction - Yinghao Li, University of Chinese Academy of Sciences, State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, P.R. China 12:45-12:50 (05min) › G4-hunter, a novel algorithm to predict G-quadruplex folding propensity through score computing - Amina Bedrat, U869, Laboratoire ARNA, IECB, Bordeaux, France 12:50-12:55 (05min) › Interaction of mutant p53 proteins with DNA quadruplexes in vitro and in cells - Marie Brázdová, Institute of Biophysics of the AS CR, v.v.i., Brno, Czech Republic 12:55-13:00 (05min) › Role of Nucleotide Excision Repair and Topoisomerase II proteins on pyridostatin-induced double-stranded DNA breaks - Charlotte Dunet, Institut de pharmacologie et de biologie structurale, CNRS, Toulouse, France 13:00-13:05 (05min) › G4s and RecQ helicases in the human malaria parasite Plasmodium falciparum - Lynne Harris, Keele University, UK 13:05-13:10 (05min) Lunch - Poster session II: Wed-P01 to Wed-P10 are posters that had a flash presentation, Wed-P11 to Wed-P52 are posters only Posters (no flash): Session II 13:10 - 15:40 (2h30) Lunch - Poster session II: Wed-P01 to Wed-P10 are posters that had a flash presentation, Wed-P11 to Wed-P52 are posters only 13:10 - 15:40 (2h30) Posters (no flash): Session II › A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands. - Anne Bourdoncle, ARNA Laboratory, Bordeaux, France 13:10-15:40 (2h30) › A Naphthalene Diimide Dyad as Selective Light Up Probe for G-quadruplex Sensing - Filippo Doria, Department of Chemistry, University of Pavia 13:10-15:40 (2h30) › Design and synthesis of a berberine dimer as a fluorescent ligand with high affinity toward G-quadruplex - Masayuki Tera, Suntory Foundation for Life Science, Osaka, Japan 13:10-15:40 (2h30) › Effect of low molecular weight ligands on the structural stability of G-quadruplexes - Petra Krafčíková, University of P.J. Safarik, Košice, Slovak Republic 13:10-15:40 (2h30) › Extended core naphtalene diimides as G-quadruplex sensors and improved anticancer compounds - Matteo Nadai, Department of Molecular Medicine, University of Padua 13:10-15:40 (2h30) › FRET-melting studies to assess the selectivity of G4 ligands - Aurore De Rache, ARNA Laboratory, IECB Bordeaux, France 13:10-15:40 (2h30) › G-quadruplex structure alteration induced by cations in relation to DNAzyme peroxidase activity - Joanna Kosman, Laboratory of Bioanalytical Chemistry, Faculty of Chemistry, Adam Mickiewicz University 13:10-15:40 (2h30) › Indolylmethyleneindanone based molecules specifically stabilize promoter quadruplex DNAs over telomeric and duplex DNAs - Divesh Kumar K V, Indian Institute of Technology [Bombay] - PRADEEPKUMAR P.I., PRADEEPKUMAR P.I. 13:10-15:40 (2h30) › Interactions of two pentanuclear lanthanide (III) metallacrowns with human telomeric DNA - Ewa Rajczak, Adam Mickiewicz University, Faculty of Chemistry, Poland 13:10-15:40 (2h30) › Investigation of the effect of G-quadruplex ligand on the expression and splicing of VEGF mRNA - Taiki Saito, Graduate school of Engineering, Tokyo University of Agriculture and Technology 13:10-15:40 (2h30) › Light induced conformational changes of the telomeric G4 DNA in complex with Zn(II) tetracarboxymethyl porphyrin - Artemy Beniaminov, Engelhardt Institute of Molecular Biology RAS, Moscow, Russia 13:10-15:40 (2h30) › Small Molecule Destabilisation of Intermolecular G-Quadruplexes - Louis Chan, Department of Chemistry (Cambridge, UK) 13:10-15:40 (2h30) › Targeting DNA quadruplexes with aromatic oligoamide foldamers - Simon Dawson, Chimie et Biologie des Membranes et des Nanoobjets 13:10-15:40 (2h30) › Terpyridine-platinum complexes derivatives as probes for telomere targeting - Sophie Bombard, INSERM UMR-S 1007, Université Paris Descartes; 13:10-15:40 (2h30) › Base Lesions in the G-tetrads and the Loops Have Varying Effects on the Folding and Stability of the Human Telomere G-quadruplex - Helena Konvalinová, Department of Biochemistry, Faculty of Science, Masaryk University 13:15-15:40 (2h25) › Divalent cations prefold a telomeric G-Quadruplex sequence into a nascent, parallel structural form - Patrick Groves, University of Gdansk, Instituto de Tecnologia Química e Biológica 13:15-15:40 (2h25) › Effective incorporation of modified nucleotides into G-quadruplex nucleic acids - Brahim Heddi, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 13:15-15:40 (2h25) › Gene regulation by RNA G-quadruplexes. New insights into the G-quadruplex structure at the 5'UTR of the BCL2 mRNA human proto-oncogene - Alicia Dominguez-Martin, University of Zürich 13:15-15:40 (2h25) › Insights from 10 µs-scale molecular dynamics simulations of human telomeric quadruplex - Barira Islam, Central European Institute of Technology, Masaryk University 13:15-15:40 (2h25) › Interaction between guanosine and a G-quadruplex with a vacant site - Si Ming Pang, School of Physical and Mathematical Sciences, NTU 13:15-15:40 (2h25) › Investigating divalent cation binding to folded G-Quadruplexes - Malgorzata Palczewska, Department of Biomedical Chemistry, University of Gdansk, POLAND 13:15-15:40 (2h25) › Joining of Multiple Duplex Stems at a Single Quadruplex Loop - Kah Wai Lim, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 13:15-15:40 (2h25) › Probing the folding dynamics of human telomeric G-quadruplex with single-molecule FRET - Mikayel Aznauryan, Centre for DNA Nanotechnology (CDNA), Aarhus University, Interdisciplinary Nanoscience Center (iNANO), Aarhus University 13:15-15:40 (2h25) › Structure, stability and cooperativity in guanine quadruplexes - Celia Fonseca Guerra, VU University Amsterdam 13:15-15:40 (2h25) › Fine-tuning of the DNA i-motif stability: lesson learnt from epigenetic regulation of telomeric DNA from plants - Silvie Trantirkova, Central European Institute of Technology - Masaryk University 13:20-15:40 (2h20) › Hairpin or i-Motif? - Elise Wright, UEA School of Pharmacy, Norwich, UK 13:20-15:40 (2h20) › Spectral characterization of i-motif enclosed in a hairpin loop for intracellular pH measurements - Anna Dembska, Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland 13:20-15:40 (2h20) › Study of the solution equilibria of two i-motif- and G-quadruplex-forming sequences found at the SMARCA4 gen - Sanae Benabou, Universitat de Barcelona 13:20-15:40 (2h20) › Discovery of a New Fluorescent Light-Up Probe Specific to Parallel G-Quadruplexes - Shuo-Bin Chen, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 13:25-15:40 (2h15) › Duplex stem-loop-containing quadruplex motifs in the human genome: A combined genomic and structural study - Vladimir Kuznetsov, Bioinformatics Institute/A*STAR 13:25-15:40 (2h15) › Evolutionarily conserved properties of telomeric DNA - Lukas Trantirek, Central European Institute of Technology - Masaryk University 13:25-15:40 (2h15) › Importance of G4 structure for the activity of metazoan origins of DNA replication - Paulina Prorok, Institut de génétique humaine - Marcel Méchali, Institut de génétique humaine 13:25-15:40 (2h15) › Short loop length and high thermal stability determine genomic instability induced by G-quadruplex forming minisatellites - Frédéric SAMAZAN, Dynamique de l'information génétique : bases fondamentales et cancer 13:25-15:40 (2h15) › A dual functional G4-DNAzyme for cells antiproliferation mediated by nucleolin targeting and hydrogen peroxide trigger - Yan Yang, Dalian Institute of Chemical Physics 13:30-15:40 (2h10) › Molecular Diagnostics Based on Quadruplex Priming Amplification and Nicking Enzyme Activity - Shota Gogichaishvili, Andronikashvili Institute of Physics, TSU, Tbilisi 0177, Republic of Georgia 13:30-15:40 (2h10) › Thermodynamic and Optical properties of Quadruplex Primers for Isothermal DNA Amplification - David Gvarjaladze, Institute of Biophysics, Ilia State University, Tbilisi 0162, Republic of Georgia 13:35-15:40 (2h05) › Braf promoter undergoes to “non-canonical”rearrangements under nearly physiological conditions - Maria Laura Greco, Dept. of Pharmaceutical and Pharmacological Sciences, via Marzolo 5,35131, Padova, Italy 13:40-15:40 (2h) › Comparing p63 to other p53 family members on binding to G4 - Matej Adámik, Institute of Biophysics of the AS CR, v.v.i., Brno, CR 13:40-15:40 (2h) › G-rich sequences within proto-oncogene KIT promoter region as targets for anticancer therapy - claudia sissi, Department of Pharmaceutical and Pharmacological Sciences, University of Padova 13:40-15:40 (2h) › Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation - Stefania Millevoi, Cancer Research Center of Toulouse (CRCT) 13:40-15:40 (2h) › The Amyloid Precursor Protein is Negatively Regulated by a 3'UTR G-quadruplex - Ezekiel Crenshaw, Drexel University 13:40-15:40 (2h) › Investigation of G-quadruplex-ligand interactions using NMR spectroscopy - Julia Wirmer-Bartoschek, J.W. Goethe Universität Frankfurt, Max von Laue Str. 7, 60439 Frankfurt 13:45-15:40 (1h55) Session 7: G4 Ligands part 2 15:40 - 18:00 (2h20) Session 7: G4 Ligands part 2 Dipankar Sen › Fine-tuning molecular tools for probing the G4 genome - Marie-Paule Teulade-Fichou, Institut Curie, Orsay, France 15:40-16:00 (20min) › Topologies selective small molecules for telemetric G-quadruplex - Kazuo Nagasawa, Tokyo University of Agriculture and Technology, Japan 16:00-16:20 (20min) › Fluorescent anti-tumor agents (FATAs) induced cancer cell death via the interaction of mitochondrial G-quadruplex DNA - Ta-Chau Chang, Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan 16:20-16:40 (20min) › Topology Specific Stabilization of Promoter over Telomeric G-Quadruplex DNAs by Designer Molecules - Pradeepkumar P.I., Indian Institute of Technology Bombay, Mumbai, India 16:40-17:00 (20min) › Photochemistry Gives the Green Light to Tel22 Thymine Targeting - Mauro Freccero, University of Pavia, Italy 17:00-17:20 (20min) › Quadruplex targeting and imaging: “stay on TASQ!” - David Monchaud, Institut de Chimie Moléculaire de l'Université de Bourgogne, Dijon, France 17:20-17:40 (20min) › Epigenetic reprogramming with G-quadruplex ligands - Guillaume Guilbaud, MRC Laboratory of Molecular Biology, Cambridge, UK 17:40-18:00 (20min) Gala Dinner 19:45 - 22:30 (2h45) Gala Dinner	Session 8: Finding New G4s or G4 Interactions 8:30 - 10:30 (2h) Session 8: Finding New G4s or G4 Interactions Paula Bates › DNA G-quadruplexes: moving toward a holistic view - Antonio Randazzo, University of Naples Federico II, Naples, Italy 08:30-08:50 (20min) › Properties, functions, and interactions of bacterial quadruplex sequences - Jörg Hartig, University of Konstanz, Germany 08:50-09:10 (20min) › Definition of a RNA G-quadruplexe, an unresolved question - Jean-Pierre Perreault, Université de Sherbrooke, Canada 09:10-09:30 (20min) › RNA Mango: A G-quadruplex for RNP complex imaging and purification - Peter Unrau, Simon Fraser University, BC, Canada 09:30-09:50 (20min) › High-resolution sequencing of DNA G-quadruplex secondary structures in the human genome - Vicki Chambers, Department of Chemistry, Cambridge, UK 09:50-10:10 (20min) › Abundant G4 structures in cells localize specifically to heterochromatin, mitotic chromosomes and some DNA fibers - Peter Lansdorp, University of Groningen, The Netherlands 10:10-10:30 (20min) Coffee break 10:30 - 11:00 (30min) Coffee break Session 9: Single Molecule G4 Studies 11:00 - 12:20 (1h20) Session 9: Single Molecule G4 Studies Concetta Giancola › Single Molecule Studies on Protein-mediated G-Quadruplex Unfolding - Hamza Balci, Department of Physics, Kent State University, USA 11:00-11:20 (20min) › Orienting G-quadruplex polarity: the quest for the elusive RNA antiparallel quadruplex - Oscar Mendoza, U869 ARNA (Inserm/Univ. Bordeaux) 11:20-11:40 (20min) › Stability of c-MYC promoter G-quadruplexes in physiological potassium concentration - Huijuan You, Mechanobiology Institute, National University of Singapore 11:40-12:00 (20min) › Single molecule FRET analysis of telomeric G-quadruplexes - Victoria Birkedal, Aarhus University, Denmark 12:00-12:20 (20min) Poster flash presentations: Session III 12:20 - 13:10 (50min) Poster flash presentations: Session III David Monchaud › Trapping G-quadruplex DNA : from molecular tools to cellular assays - Elodie Morel, Institut Curie, Paris, France 12:20-12:25 (05min) › Topologically Controlled DNA and RNA G-Quadruplexes - Laureen Bonnat, Département de Chimie Moléculaire, UJF Grenoble, France 12:25-12:30 (05min) › G-quadruplex with (4n-1) guanines in the G-tetrad core: Formation of a G-triad·H2O complex - Nerea Martin-Pintado, Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 12:30-12:35 (05min) › Locking VEGF aptamer into a single G-quadruplex structure - Maja Marušič, Slovenian NMR Center, National Institute of Chemistry, Ljubljana, Slovenia 12:35-12:40 (05min) › Multi-modal fluorescence imaging of G-quadruplex structures in human cells. - Aurélien Laguerre, Institut de Chimie Moléculaire, Université de Bourgogne, Dijon, France 12:40-12:45 (05min) › Study of the impact of a highly conserved G-quadruplex motif on Xist gene expression and function during X-chromosome inactivation. - Sarra Merzouk, European Research Institute for the Biology of Ageing University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 12:45-12:50 (05min) › Cancer cells stimulated by DNA G-quadruplex ligands: an NMR-based metabolomics study - Nunzia Iaccarino, University of Naples Federico II, Napoli, Italy 12:50-12:55 (05min) › Identification and characterization of promoter-G4-associated proteins - Silvia Götz, Department of Biochemistry, University of Wuerzburg, Germany 12:55-13:00 (05min) › Connection of an ubiquitin ligase to genome stability at G-quadruplex structures - Katharina Wanzek, Department of Biochemistry, University of Wuerzburg, Germany 13:00-13:05 (05min) › Detection of cellular RNA G-quadruplexes-binding proteins - Tatsuo Serikawa, Technische Universität Berlin, Germany 13:05-13:10 (05min) Lunch - Poster session III: Thu-P01 to Thu-P10 are posters that had a flash presentation, Thu-P11 to Thu-P51 are posters only Posters (no flash): Session III 13:10 - 15:40 (2h30) Lunch - Poster session III: Thu-P01 to Thu-P10 are posters that had a flash presentation, Thu-P11 to Thu-P51 are posters only 13:10 - 15:40 (2h30) Posters (no flash): Session III › A new phenanthroline derivative for G4-Fluorescent Intercalator Displacement - Florence Mahuteau-Betzer, Institut Curie, Orsay, France 13:10-15:40 (2h30) › Fluorescence-Based Studies on Ligand Binding: The G-Quadruplex Perspective - Beatrice Karg, Ernst-Moritz-Arndt-University Greifswald, Institute of Biochemistry 13:10-15:40 (2h30) › G-Quadruplex Ligands Exhibit Differential G-tetrad Selectivity - Daniel Le, Department of Chemistry (Cambridge, UK) 13:10-15:40 (2h30) › Interaction of new carbazole ligand containing imidazole moiety with different forms of nucleic acids - spectroscopic study and bioactivity - Agata Głuszyńska, Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland 13:10-15:40 (2h30) › Interaction of phenantroline ligands with G-quadruplexes sequences - Nassima Meriem Gueddouda, ARNA Laboratory, Bordeaux, France 13:10-15:40 (2h30) › Natural quaternary benzo[c]phenantridine alkaloids selectively stabilize G-quadruplexes - Raimundo Gargallo, Universitat de Barcelona 13:10-15:40 (2h30) › The Interaction of Bis-Benzimide H33258 and Bis-Benzimide H33442 with G-quadruplexes - Erika Demkovičova, Department of Biochemistry, Institute of Chemistry, Faculty of Sciences, Pavol Jozef Safarik University 13:10-15:40 (2h30) › Characterization of Cationic DNA Transfection Agents Binding to Supramolecular G-DNA - Thomas Marsh, University of St. Thomas, St. Paul, MN, USA 13:15-15:40 (2h25) › Ion-specific self-assembly of lipophilic guanosine derivative in thin surface films - Lucija Coga, Faculty of Mathematics and Physics [Ljubljana] 13:15-15:40 (2h25) › SAXS analysis of anisotropic hydrogels made by G-enriched GMP quadruplexes - Federica Carducci, Università Politecnica delle Marche 13:15-15:40 (2h25) › Specific Effect of 5'GC-ends on the Self-assembly of Short G-rich Oligonucleotides - Lea Spindler, Faculty of Mechanical Engineering, University of Maribor, Department of Complex Matter, Jozef Stefan Institute 13:15-15:40 (2h25) › The Guanosine 5'- monophosphate self-assembly: effects of silver ions - Silvia Moscatelli, Università Politecnica delle Marche 13:15-15:40 (2h25) › Duplex Formation in Bulges of G-Quadruplexes - Thi Quynh Ngoc Nguyen, Nanyang Technological University 13:20-15:40 (2h20) › Equilibrium and non-equilibrium thermodynamics: yin and yang of G-quadruplex formation - Iztok Prislan, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Vecna pot 113, 1000 Ljubljana 13:20-15:40 (2h20) › G4s with Single-Nucleotide and Non-Nucleotide Loops: Monomolecular Parallel Folding and Aggregation - Galina Pozmogova, SRI of Physical-Chemical Medicine, Moscow, Russia 13:20-15:40 (2h20) › Rotation of Guanine Amino Group in G-Quadruplex Nucleic Acids - Fernaldo Richtia Winnerdy, Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 13:20-15:40 (2h20) › NMR study of DNA G-quadruplex formed in human KRAS oncogene promoter - Stefaniia Ivashchenko, ARNA laboratory, Bordeaux, France 13:25-15:40 (2h15) › Oligourea foldamer mimics in cys2his2 zinc finger peptide: towards composite protein - Vasantha Kumar M.V., ARNA laboratory, Bordeaux, France 13:25-15:40 (2h15) › On the Polymorphism of Telomeric G-quadruplexes Controlled by DNA Concentration and Temperature - Peter Mojzeš, Institute of Physics, Faculty of Mathematics and Physics, Charles University in Prague [Prague] 13:25-15:40 (2h15) › Probing G-quadruplex folding and ligand interaction in living cells using NMR spectroscopy. - Gilmar Salgado, ARNA laboratory, Bordeaux, France 13:25-15:40 (2h15) › Spectroscopic studies of guanine quadruplex in the regulatory region of the POU5F1 gene - Iva Kejnovská, CEITEC - Central European Institute of Technology, Brno, Czech Republic, Institute of Biophysics of the Academy of Sciences of the Czech Rep., Brno, Czech Republic 13:25-15:40 (2h15) › Spectroscopic study of Quadruplex-Duplex Hybrids - Karolina Czajczynska, Polish Academy of Sciences (POLAND) 13:25-15:40 (2h15) › Structural Characterization of a Dimer of RNA Duplexes Composed of CGG Trinucleotide Repeats: a Novel Architecture of RNA Quadruplexes - Dorota Gudanis, Polish Academy of Sciences (POLAND) 13:25-15:40 (2h15) › The Biological Function of G-quadruplex within WNT1 Gene Promoter and its Conformational Transition - Margaret Kuo, Institute of Atomic and Molecular Sciences, Academia Sinica 13:25-15:40 (2h15) › The GBA Formalism: a Rational Approach to Constructing DNA G-Quadruplexes - Mateus Webba da Silva, Biomedical Sciences Research Institute, University of Ulster 13:25-15:40 (2h15) › The Oxidative Damage on Telomeric G-quadruplex Structures: a Potential Protecting Role of the Loop Thymines - Luigi Petraccone, Dep. of Chemical Sciences, Naples University Federico II 13:25-15:40 (2h15) › The predominant formation of a left-handed G-quadruplex in NH4+ - Blaž Bakalar, Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 13:25-15:40 (2h15) › Thermodynamic, structural and biological features of thrombin binding aptamer modified with novel UNA derivative - Anna Pasternak, Institute of Bioorganic Chemistry, PAS, Poznan, Poland 13:25-15:40 (2h15) › Enantioselective oxidation reaction with G-quadruplex DNA-based catalysts - Cheng Mingpan, University of Chinese Academy of Sciences, State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences 13:30-15:40 (2h10) › Propensity of Double-Headed-Oligonucleotides to form parallel G-Quadruplex structures - Fabrizia Nici, Universita di Napoli Federico II 13:30-15:40 (2h10) › Structural elucidation of Binary and Ternary Complexes of Thrombin with DNA-Aptamers - Filomena Sica, Department of Chemical Sciences, University of Naples `Federco II' 13:35-15:40 (2h05) › G4RNA: an RNA G-quadruplex database - Jean-Michel Garant, Université de Sherbrooke 13:40-15:40 (2h) › Identification of proteins binding to the parallel arrangement of telomeric G-quadruplex DNA - Jussara Amato, University of Naples Federico II [Naples] 13:40-15:40 (2h) › Isolation of G-quadruplexes by pull-down strategy using telomestatin derivatives - Shadi Sedghi Masoud, Tokyo University of Agriculture and Technology 13:40-15:40 (2h) › Nucleic Acid Detection and Quantification Methods based on DNA Quadruplexes - Levan Lomidze, Institute of Biophysics, Ilia State University 13:40-15:40 (2h) › A triarylpyridine G-quadruplex ligand promotes autophagy and cell death in HeLa cancer cells - Paul Bensadoun & Mojgan Djavaheri-Mergny, INSERM U916 VINCO & Univ. Bordeaux 13:45-15:40 (1h55) › G-quadruplexes in pathogenic microbes: a common route to virulence control? - Catherine Merrick, Keele University, UK 13:45-15:40 (1h55) › The RNA binding protein hnRNP A1 regulates Ron mRNA translation and breast cancer metastasis - Anne Cammas, Centre de Recherches en Cancérologie de Toulouse 13:45-15:40 (1h55) › G-quadruplexes, G4 resolvases and posttrancriptionnal regulation - Angelique Pipier, Institut de pharmacologie et de biologie structurale 13:50-15:40 (1h50) › Processing of double-R-loops in (CAG)/(CTG) and C9orf72 (GGGGCC)/(GGCCCC) repeats causes instability - Mila Mirceta, Department of Genetics, The Hospital for Sick Children, Toronto 13:50-15:40 (1h50) › The nuclear Pfh1 DNA helicase efficiently unwinds G-quadruplex DNA - Nasim Sabouri, Umea University (SWEDEN) 13:50-15:40 (1h50) Session 10: The Relation of G4 to Disease 15:40 - 18:10 (2h30) Session 10: The Relation of G4 to Disease Jonathan B. Chaires › Unusual RNA / DNA structures formed by disease-associated C9orf72 repeats (GGGGCC)n/(GGCCCC)n: Roles in mutagenesis and pathogenesis - Christopher Pearson, The Hospital for Sick Children, Toronto, Canada 15:40-16:00 (20min) › T7 RNA Polymerase Controls a Strand-Biased Formation of G-Quadruplex in Transcription of DNA Duplex - Zheng Tan, Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China 16:00-16:20 (20min) › Translation Suppression by G-quadruplex - Naoki Sugimoto, Konan University, Kobe, Japan 16:20-16:40 (20min) › DNA Damage Changes the Duplex-Quadruplex Equilibrium in Promoters and Impacts Transcription - Aaron Fleming, University of Utah, USA 16:40-17:00 (20min) › Resistance to 360A induces telomere alteration and genome-wide quadruplex reprogramming of gene transcription - Jean-François Riou, Laboratoire Structure et Instabilité des Génomes, Museum National d'Histoire Naturelle, Paris, France 17:00-17:20 (20min) › G-quadruplexes in the herpes simplex virus-1: presence, function and targeting in vitro and in infected cells - Sara Richter, Department of Molecular Medicine, University of Padua, Italy 17:20-17:40 (20min) › G-quadruplex Genomic Targets for Transcriptional Regulation - Nancy Maizels, University of Washington, Seattle, WA, USA 17:40-18:10 (30min) Closing - Awards ceremony 18:10 - 18:20 (10min) Closing - Awards ceremony Valérie Gabelica

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