5th International Meeting on Quadruplex Nucleic Acids

›8:30 (2h)

Session 8: Finding New G4s or G4 Interactions
Paula Bates

8:30 - 10:30 (2h)

Session 8: Finding New G4s or G4 Interactions

Paula Bates

› DNA G-quadruplexes: moving toward a holistic view - Antonio Randazzo, University of Naples Federico II, Naples, Italy 08:30-08:50 (20min)

› Properties, functions, and interactions of bacterial quadruplex sequences - Jörg Hartig, University of Konstanz, Germany 08:50-09:10 (20min)

› Definition of a RNA G-quadruplexe, an unresolved question - Jean-Pierre Perreault, Université de Sherbrooke, Canada 09:10-09:30 (20min)

› RNA Mango: A G-quadruplex for RNP complex imaging and purification - Peter Unrau, Simon Fraser University, BC, Canada 09:30-09:50 (20min)

› High-resolution sequencing of DNA G-quadruplex secondary structures in the human genome - Vicki Chambers, Department of Chemistry, Cambridge, UK 09:50-10:10 (20min)

› Abundant G4 structures in cells localize specifically to heterochromatin, mitotic chromosomes and some DNA fibers - Peter Lansdorp, University of Groningen, The Netherlands 10:10-10:30 (20min)

›10:30 (30min)

Coffee break

10:30 - 11:00 (30min)

Coffee break

›11:00 (1h20)

Session 9: Single Molecule G4 Studies
Concetta Giancola

11:00 - 12:20 (1h20)

Session 9: Single Molecule G4 Studies

Concetta Giancola

› Single Molecule Studies on Protein-mediated G-Quadruplex Unfolding - Hamza Balci, Department of Physics, Kent State University, USA 11:00-11:20 (20min)

› Orienting G-quadruplex polarity: the quest for the elusive RNA antiparallel quadruplex - Oscar Mendoza, U869 ARNA (Inserm/Univ. Bordeaux) 11:20-11:40 (20min)

› Stability of c-MYC promoter G-quadruplexes in physiological potassium concentration - Huijuan You, Mechanobiology Institute, National University of Singapore 11:40-12:00 (20min)

› Single molecule FRET analysis of telomeric G-quadruplexes - Victoria Birkedal, Aarhus University, Denmark 12:00-12:20 (20min)

›12:20 (50min)

Poster flash presentations: Session III
David Monchaud

12:20 - 13:10 (50min)

Poster flash presentations: Session III

David Monchaud

› Trapping G-quadruplex DNA : from molecular tools to cellular assays - Elodie Morel, Institut Curie, Paris, France 12:20-12:25 (05min)

› Topologically Controlled DNA and RNA G-Quadruplexes - Laureen Bonnat, Département de Chimie Moléculaire, UJF Grenoble, France 12:25-12:30 (05min)

› G-quadruplex with (4n-1) guanines in the G-tetrad core: Formation of a G-triad·H2O complex - Nerea Martin-Pintado, Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 12:30-12:35 (05min)

› Locking VEGF aptamer into a single G-quadruplex structure - Maja Marušič, Slovenian NMR Center, National Institute of Chemistry, Ljubljana, Slovenia 12:35-12:40 (05min)

› Multi-modal fluorescence imaging of G-quadruplex structures in human cells. - Aurélien Laguerre, Institut de Chimie Moléculaire, Université de Bourgogne, Dijon, France 12:40-12:45 (05min)

› Study of the impact of a highly conserved G-quadruplex motif on Xist gene expression and function during X-chromosome inactivation. - Sarra Merzouk, European Research Institute for the Biology of Ageing University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 12:45-12:50 (05min)

› Cancer cells stimulated by DNA G-quadruplex ligands: an NMR-based metabolomics study - Nunzia Iaccarino, University of Naples Federico II, Napoli, Italy 12:50-12:55 (05min)

› Identification and characterization of promoter-G4-associated proteins - Silvia Götz, Department of Biochemistry, University of Wuerzburg, Germany 12:55-13:00 (05min)

› Connection of an ubiquitin ligase to genome stability at G-quadruplex structures - Katharina Wanzek, Department of Biochemistry, University of Wuerzburg, Germany 13:00-13:05 (05min)

› Detection of cellular RNA G-quadruplexes-binding proteins - Tatsuo Serikawa, Technische Universität Berlin, Germany 13:05-13:10 (05min)

›13:10 (2h30)

Lunch - Poster session III: Thu-P01 to Thu-P10 are posters that had a flash presentation, Thu-P11 to Thu-P51 are posters only

13:10 - 15:40 (2h30)

Lunch - Poster session III: Thu-P01 to Thu-P10 are posters that had a flash presentation, Thu-P11 to Thu-P51 are posters only

›13:10 (2h30)

Posters (no flash): Session III

13:10 - 15:40 (2h30)

Posters (no flash): Session III

› A new phenanthroline derivative for G4-Fluorescent Intercalator Displacement - Florence Mahuteau-Betzer, Institut Curie, Orsay, France 13:10-15:40 (2h30)

› Fluorescence-Based Studies on Ligand Binding: The G-Quadruplex Perspective - Beatrice Karg, Ernst-Moritz-Arndt-University Greifswald, Institute of Biochemistry 13:10-15:40 (2h30)

› G-Quadruplex Ligands Exhibit Differential G-tetrad Selectivity - Daniel Le, Department of Chemistry (Cambridge, UK) 13:10-15:40 (2h30)

› Interaction of new carbazole ligand containing imidazole moiety with different forms of nucleic acids - spectroscopic study and bioactivity - Agata Głuszyńska, Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland 13:10-15:40 (2h30)

› Interaction of phenantroline ligands with G-quadruplexes sequences - Nassima Meriem Gueddouda, ARNA Laboratory, Bordeaux, France 13:10-15:40 (2h30)

› Natural quaternary benzo[c]phenantridine alkaloids selectively stabilize G-quadruplexes - Raimundo Gargallo, Universitat de Barcelona 13:10-15:40 (2h30)

› The Interaction of Bis-Benzimide H33258 and Bis-Benzimide H33442 with G-quadruplexes - Erika Demkovičova, Department of Biochemistry, Institute of Chemistry, Faculty of Sciences, Pavol Jozef Safarik University 13:10-15:40 (2h30)

› Characterization of Cationic DNA Transfection Agents Binding to Supramolecular G-DNA - Thomas Marsh, University of St. Thomas, St. Paul, MN, USA 13:15-15:40 (2h25)

› Ion-specific self-assembly of lipophilic guanosine derivative in thin surface films - Lucija Coga, Faculty of Mathematics and Physics [Ljubljana] 13:15-15:40 (2h25)

› SAXS analysis of anisotropic hydrogels made by G-enriched GMP quadruplexes - Federica Carducci, Università Politecnica delle Marche 13:15-15:40 (2h25)

› Specific Effect of 5'GC-ends on the Self-assembly of Short G-rich Oligonucleotides - Lea Spindler, Faculty of Mechanical Engineering, University of Maribor, Department of Complex Matter, Jozef Stefan Institute 13:15-15:40 (2h25)

› The Guanosine 5'- monophosphate self-assembly: effects of silver ions - Silvia Moscatelli, Università Politecnica delle Marche 13:15-15:40 (2h25)

› Duplex Formation in Bulges of G-Quadruplexes - Thi Quynh Ngoc Nguyen, Nanyang Technological University 13:20-15:40 (2h20)

› Equilibrium and non-equilibrium thermodynamics: yin and yang of G-quadruplex formation - Iztok Prislan, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Vecna pot 113, 1000 Ljubljana 13:20-15:40 (2h20)

› G4s with Single-Nucleotide and Non-Nucleotide Loops: Monomolecular Parallel Folding and Aggregation - Galina Pozmogova, SRI of Physical-Chemical Medicine, Moscow, Russia 13:20-15:40 (2h20)

› Rotation of Guanine Amino Group in G-Quadruplex Nucleic Acids - Fernaldo Richtia Winnerdy, Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 13:20-15:40 (2h20)

› NMR study of DNA G-quadruplex formed in human KRAS oncogene promoter - Stefaniia Ivashchenko, ARNA laboratory, Bordeaux, France 13:25-15:40 (2h15)

› Oligourea foldamer mimics in cys2his2 zinc finger peptide: towards composite protein - Vasantha Kumar M.V., ARNA laboratory, Bordeaux, France 13:25-15:40 (2h15)

› On the Polymorphism of Telomeric G-quadruplexes Controlled by DNA Concentration and Temperature - Peter Mojzeš, Institute of Physics, Faculty of Mathematics and Physics, Charles University in Prague [Prague] 13:25-15:40 (2h15)

› Probing G-quadruplex folding and ligand interaction in living cells using NMR spectroscopy. - Gilmar Salgado, ARNA laboratory, Bordeaux, France 13:25-15:40 (2h15)

› Spectroscopic studies of guanine quadruplex in the regulatory region of the POU5F1 gene - Iva Kejnovská, CEITEC - Central European Institute of Technology, Brno, Czech Republic, Institute of Biophysics of the Academy of Sciences of the Czech Rep., Brno, Czech Republic 13:25-15:40 (2h15)

› Spectroscopic study of Quadruplex-Duplex Hybrids - Karolina Czajczynska, Polish Academy of Sciences (POLAND) 13:25-15:40 (2h15)

› Structural Characterization of a Dimer of RNA Duplexes Composed of CGG Trinucleotide Repeats: a Novel Architecture of RNA Quadruplexes - Dorota Gudanis, Polish Academy of Sciences (POLAND) 13:25-15:40 (2h15)

› The Biological Function of G-quadruplex within WNT1 Gene Promoter and its Conformational Transition - Margaret Kuo, Institute of Atomic and Molecular Sciences, Academia Sinica 13:25-15:40 (2h15)

› The GBA Formalism: a Rational Approach to Constructing DNA G-Quadruplexes - Mateus Webba da Silva, Biomedical Sciences Research Institute, University of Ulster 13:25-15:40 (2h15)

› The Oxidative Damage on Telomeric G-quadruplex Structures: a Potential Protecting Role of the Loop Thymines - Luigi Petraccone, Dep. of Chemical Sciences, Naples University Federico II 13:25-15:40 (2h15)

› The predominant formation of a left-handed G-quadruplex in NH4+ - Blaž Bakalar, Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 13:25-15:40 (2h15)

› Thermodynamic, structural and biological features of thrombin binding aptamer modified with novel UNA derivative - Anna Pasternak, Institute of Bioorganic Chemistry, PAS, Poznan, Poland 13:25-15:40 (2h15)

› Enantioselective oxidation reaction with G-quadruplex DNA-based catalysts - Cheng Mingpan, University of Chinese Academy of Sciences, State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences 13:30-15:40 (2h10)

› Propensity of Double-Headed-Oligonucleotides to form parallel G-Quadruplex structures - Fabrizia Nici, Universita di Napoli Federico II 13:30-15:40 (2h10)

› Structural elucidation of Binary and Ternary Complexes of Thrombin with DNA-Aptamers - Filomena Sica, Department of Chemical Sciences, University of Naples `Federco II' 13:35-15:40 (2h05)

› G4RNA: an RNA G-quadruplex database - Jean-Michel Garant, Université de Sherbrooke 13:40-15:40 (2h)

› Identification of proteins binding to the parallel arrangement of telomeric G-quadruplex DNA - Jussara Amato, University of Naples Federico II [Naples] 13:40-15:40 (2h)

› Isolation of G-quadruplexes by pull-down strategy using telomestatin derivatives - Shadi Sedghi Masoud, Tokyo University of Agriculture and Technology 13:40-15:40 (2h)

› Nucleic Acid Detection and Quantification Methods based on DNA Quadruplexes - Levan Lomidze, Institute of Biophysics, Ilia State University 13:40-15:40 (2h)

› A triarylpyridine G-quadruplex ligand promotes autophagy and cell death in HeLa cancer cells - Paul Bensadoun & Mojgan Djavaheri-Mergny, INSERM U916 VINCO & Univ. Bordeaux 13:45-15:40 (1h55)

› G-quadruplexes in pathogenic microbes: a common route to virulence control? - Catherine Merrick, Keele University, UK 13:45-15:40 (1h55)

› The RNA binding protein hnRNP A1 regulates Ron mRNA translation and breast cancer metastasis - Anne Cammas, Centre de Recherches en Cancérologie de Toulouse 13:45-15:40 (1h55)

› G-quadruplexes, G4 resolvases and posttrancriptionnal regulation - Angelique Pipier, Institut de pharmacologie et de biologie structurale 13:50-15:40 (1h50)

› Processing of double-R-loops in (CAG)/(CTG) and C9orf72 (GGGGCC)/(GGCCCC) repeats causes instability - Mila Mirceta, Department of Genetics, The Hospital for Sick Children, Toronto 13:50-15:40 (1h50)

› The nuclear Pfh1 DNA helicase efficiently unwinds G-quadruplex DNA - Nasim Sabouri, Umea University (SWEDEN) 13:50-15:40 (1h50)

›15:40 (2h30)

Session 10: The Relation of G4 to Disease
Jonathan B. Chaires

15:40 - 18:10 (2h30)

Session 10: The Relation of G4 to Disease

Jonathan B. Chaires

› Unusual RNA / DNA structures formed by disease-associated C9orf72 repeats (GGGGCC)n/(GGCCCC)n: Roles in mutagenesis and pathogenesis - Christopher Pearson, The Hospital for Sick Children, Toronto, Canada 15:40-16:00 (20min)

› T7 RNA Polymerase Controls a Strand-Biased Formation of G-Quadruplex in Transcription of DNA Duplex - Zheng Tan, Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China 16:00-16:20 (20min)

› Translation Suppression by G-quadruplex - Naoki Sugimoto, Konan University, Kobe, Japan 16:20-16:40 (20min)

› DNA Damage Changes the Duplex-Quadruplex Equilibrium in Promoters and Impacts Transcription - Aaron Fleming, University of Utah, USA 16:40-17:00 (20min)

› Resistance to 360A induces telomere alteration and genome-wide quadruplex reprogramming of gene transcription - Jean-François Riou, Laboratoire Structure et Instabilité des Génomes, Museum National d'Histoire Naturelle, Paris, France 17:00-17:20 (20min)

› G-quadruplexes in the herpes simplex virus-1: presence, function and targeting in vitro and in infected cells - Sara Richter, Department of Molecular Medicine, University of Padua, Italy 17:20-17:40 (20min)

› G-quadruplex Genomic Targets for Transcriptional Regulation - Nancy Maizels, University of Washington, Seattle, WA, USA 17:40-18:10 (30min)

›18:10 (10min)

Closing - Awards ceremony
Valérie Gabelica

18:10 - 18:20 (10min)

Closing - Awards ceremony

Valérie Gabelica