08:00
09:00
10:00
11:00
12:00
13:00
14:00
15:00
16:00
17:00
18:00
19:00
20:00
21:00
22:00
8:00 - 9:00 (1h)
Arrival and registration
Collecting badges and conference materials at the reception desk
9:00 - 9:10 (10min)
Opening address
Jean-Louis Mergny
9:10 - 9:40 (30min)
Introduction to G-quadruplexes
› Fifty shades of G: Quadruplexes come in many forms!
- Jean-Louis Mergny, Institut Européen de Chimie et Biologie
09:10-09:40 (30min)
9:40 - 11:00 (1h20)
Session 1: G4 Folding
Nancy Maizels
› Promoter and Telomeric Quadruplexes: Size Does Matter
- Jonathan Chaires, James Graham Brown Cancer Center, Louisville, KY, USA
09:40-10:00 (20min)
› Thermodynamics of human telomere quadruplex binding-coupled structural alterations
- Jurij Lah, University of Ljubljana, Slovenia
10:00-10:20 (20min)
› Advanced computational studies of G-quadruplex folding and topological preferences.
- Jiri Sponer, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
10:20-10:40 (20min)
› Mass spectrometry reveals new aspects of human telomeric G-quadruplex folding pathways in potassium
- Valentina D'Atri, U869 ARNA (Inserm/Univ. Bordeaux), Pessac, France
10:40-11:00 (20min)
11:00 - 11:30 (30min)
Coffee break
11:30 - 13:10 (1h40)
Session 2: G4 Ligands part 1
Marie-Paule Teulade-Fichou
› G-quadruplexes and heme: strange partners from SELEX to biology
- Dipankar Sen, Simon Fraser University, British Columbia, Canada
11:30-11:50 (20min)
› Heme-DNA Complexes
- Yasuhiko Yamamoto, University of Tsukuba, Japan
11:50-12:10 (20min)
› The Story of NMM, my Favorite Quadruplex Ligand
- Liliya Yatsunyk, Swarthmore College, USA
12:10-12:30 (20min)
› An Integrated Platform for Quadruplex-Targeted Drug Discovery
- John Trent, James Graham Brown Cancer Center, Louisville, KY, USA.
12:30-12:50 (20min)
› The design and development of G4-binding small molecules targeting pancreatic cancer
- Stephen Neidle, School of Pharmacy, UCL, London, UK
12:50-13:10 (20min)
13:10 - 14:30 (1h20)
Lunch
14:30 - 15:50 (1h20)
Session 3: G4s in Cancer
Lukas Trantirek
› Common hTERT Promoter Quadruplex-disrupting Mutations Provide a Target for Melanoma Therapy
- Donald Miller, Brown Cancer Center, University of Louisville, KY, USA
14:30-14:50 (20min)
› TERRA G-quadruplex as a potential modifier of the genome-wide gene expression and cancer behavior in vivo
- Hiroyuki Seimiya, Japanese Foundation for Cancer Research, Tokyo, Japan
14:50-15:10 (20min)
› G-Quadruplexes and Gold: A Winning Combination Against Cancer?
- Paula Bates, University of Louisville, KY, USA
15:10-15:30 (20min)
› Involvement of G-quadruplexes in the Alternative Lengthening of Telomere (ALT) mechanism in human cancer cells
- Tracy Bryan, Children's Medical Research Institute, University of Sydney, Australia
15:30-15:50 (20min)
15:50 - 16:20 (30min)
Coffee break
16:20 - 17:20 (1h)
Session 4: Novel G4 Structures
Antonio Randazzo
› Folding intermediates and fascinating new structures
- Janez Plavec, Slovenian NMR centre, Ljubljana, Slovenia
16:20-16:40 (20min)
› Telomeric Quadruplex/Duplex Interfaces: A Target for Drug Design
- Gary Parkinson, University College London, School of Pharmacy, London, UK
16:40-17:00 (20min)
› Structure, engineering, and recognition of G-quadruplexes
- Anh Tuan Phan, Nanyang Technological University, Singapore
17:00-17:20 (20min)
17:20 - 18:10 (50min)
Poster flash presentations: Session I
Liliya Yatsunyk
› Racemic DNA Crystallography helps to determine G4 structures
- Pradeep MANDAL, Chimie et Biologie des Membranes et des Nanoobjets, Institut Européen de Chimie et Biologie, Bordeaux, France
17:20-17:25 (05min)
› Editing Tetrad Polarities in Unimolecular G-Quadruplexes
- Jonathan Dickerhoff, Ernst-Moritz-Arndt University Greifswald, Institute of Biochemistry, Germany
17:25-17:30 (05min)
› G-quadruplex with DNA base lesions: Xanthine and 8-oxoguanine
- Vee Vee Cheong, Nanyang Technological University, Singapore
17:30-17:35 (05min)
› Dictyostelium, a new model to quadruplex studies
- Souheila Amor, ARNA laboratory, Bordeaux, France
17:35-17:40 (05min)
› Unlocking the therapeutic potential of 5'UTR RNA G-quadruplexes with Peptide Nucleic Acid (PNA)-small molecule conjugates
- Douglas Vair-Turnbull, Imperial College London, UK
17:40-17:45 (05min)
› Targeted Detection of G-Quadruplexes in Cellular RNAs
- chun kit kwok, Department of Chemistry (Cambridge, UK), Cancer Research UK Cambridge Institute
17:45-17:50 (05min)
› A Novel Antibody Determines the Parallel G-quadruplex Sequence Consensus and Preferential Telomeric G4 Conformation in Human Cell
- Huiyun Liu, School of Pharmaceutical Sciences, Sun Yat-sen University, P.R. China
17:50-17:55 (05min)
› Guanine oxidation in the G4-containing sequence of KRAS is an oxidative lesion or an epigenetic transcription marker?
- Marco Quercia, Department of Medical and Biological Sciences, University of Udine, Italy
17:55-18:00 (05min)
› A G-quadruplex forming aptamer potently inhibits HIV-1 entry into the host cell
- Martina Tassinari, Department of Molecular Medicine, University of Padua, Italy
18:00-18:05 (05min)
› G-Quadruplexes and MicroRNAs: a Dynamic Duo
- Samuel Rouleau, Université de Sherbrooke, Canada
18:05-18:10 (05min)
18:10 - 21:00 (2h50)
Wine & Cheese party - Poster session I: Tue-P01 to Tue-P10 are posters that had a flash presentation, Tue-P11 to Tue-P52 are posters only
18:10 - 21:00 (2h50)
Posters (no flash): Session I
› Binding Studies of N5-Methylated Indolo[3,2-b]quinoline Derivatives to G-Quadruplexes of Different Topology
- Andrea Funke
18:10-21:00 (2h50)
› Characterization of interactions between Pt-ttpy and G-quadruplexes originating from promoter region of c-myc gene
- Marko Trajkovski, National Institute of Chemistry Slovenia
18:10-21:00 (2h50)
› Dissection of energetics of ligand binding to the human telomere 3' sequence of d(AGGG(TTAGGG)3)
- Matjaz Boncina, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Vecna pot 113, 1000 Ljubljana
18:10-21:00 (2h50)
› Dynamics of Cy3-analogues attached to a G-quadruplex - interpreting FRET through MD simulations
- Siri Søndergaard, Aarhus University [Aarhus]
18:10-21:00 (2h50)
› G4-OAS in action: Discovery and evaluation of novel G4-binders
- Daniela Montesarchio, Department of Chemical Sciences, University of Naples Federico II
18:10-21:00 (2h50)
› Helquats: novel class of G-quadruplex ligands
- Jaroslav Kozák, Institute of Organic Chemistry and Biochemistry, v.v.i., AS CR, Czech Republic
18:10-21:00 (2h50)
› How different sugar presentation in G-quadruplex ligands affect binding affinity and selectivity to G-quadruplex
- Matilde Arevalo-Ruiz, Instituto de Parasitologia y Biomedicina
18:10-21:00 (2h50)
› Interaction of G-quadruplex derived from NHE III1 region of c-MYC oncogene (Pu22) with small carbazole ligands
- Martyna Kuta, Faculty of Chemistry, Adam Mickiewicz University (POLAND) - Agata Głuszyńska, Faculty of Chemistry, Adam Mickiewicz University (POLAND)
18:10-21:00 (2h50)
› Investigation on the interaction between a Gold(I)-caffeine complex and human telomeric DNA
- Francesco Papi, university of florence
18:10-21:00 (2h50)
› Ligand Induced Conformational Preorganization of Loops and Grooves of c-MYC G-Quadruplex DNA and its Implications in Structure Specific Drug Design
- S Harikrishna, Indian Institute of Technology [Bombay]
18:10-21:00 (2h50)
› Localizing K+ and ligands in G-quadruplexes using a new MS/MS fragmentation technique: electron photodetachment dissociation (EPD)
- Dababrata Paul, INSERM U869, ARNA laboratory Bordeaux F-33000, France, Univ. Bordeaux IECB, ARNA laboratory Pessac F-33600, France
18:10-21:00 (2h50)
› Recognition Agents for Nucleic Acid Quadruplex Structures in Cells
- Lois Bright, University of Birmingham
18:10-21:00 (2h50)
› Synthesis of G-quadruplex ligands by dual interaction strategy and evaluation of their stabilization ability
- YUE MA, Tokyo University of Agriculture and Technology
18:10-21:00 (2h50)
› Testing G4 ligand activity using an in vitro translation system
- HONG ANH TRUONG, Nanyang Technological University
18:10-21:00 (2h50)
› Ultrafast electron transfer in complexes of Doxorubicin with human telomeric G-quadruplexes probed by femtosecond fluorescence spectroscopy
- Pascale Changenet-Barret, Laboratoire d'Optique et Biosciences, Palaiseau, France
18:10-21:00 (2h50)
› A G-rich sequence adopts a tetrahelical DNA fold different from G-quadruplexes
- Vojc Kocman, Slovenian NMR Centre, National Institute of Chemistry
18:15-21:00 (2h45)
› A Rational Approach to Constructing DNA G-Quadruplexes
- Scarlett Dvorkin, University of Ulster
18:15-21:00 (2h45)
› Concentration-Dependent Behaviour of H-Tel and 19 Related ODNs
- Rob Macgregor, Department of Pharmaceutical Sciences, U. Toronto
18:15-21:00 (2h45)
› Formation of G-quadruplexes in poly-G sequences: Structure of a propeller-type parallel-stranded G-quadruplex formed by a G15 stretch
- Anjali Sengar, Nanyang Technological University
18:15-21:00 (2h45)
› G-quadruplex production and stabilization
- Carla Cruz, CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior
18:15-21:00 (2h45)
› Intermediates in Folding of Human Telomeric Quadruplexes Studied by Molecular Dynamics Simulations
- Petr Stadlbauer, Institute of Biophysics, Academy of Sciences of the Czech Republic
18:15-21:00 (2h45)
› Solution structure of a DNA quadruplex containing ALS and FTD related GGGGCC repeat stabilized by 8-bromodeoxyguanosine substitution
- Jasna Brcic, Slovenian NMR Center, National Institute of Chemistry
18:15-21:00 (2h45)
› Structural properties of G-quadruplex formed in the oncogene RET promoter sequences
- Petra Tothova, Department of Biochemistry, Institute of Chemistry, Faculty of Sciences, Pavol Jozef Safarik University
18:15-21:00 (2h45)
› The influence of RNA sequence, concentration, type of cation and cellular environment on the folding of RNA G-quadruplex composed of AGG, CGG and UGG repeats
- Magdalena Malgowska, Institute of Bioorganic Chemistry, Poznan, Poland
18:15-21:00 (2h45)
› Unravelling biologically relevant RNA G-quadruplexes: single molecule studies and metal ion dependency
- Helena Guiset Miserachs, Department of Chemistry, University of Zürich
18:15-21:00 (2h45)
› Biotechnological applications of Quadruplexes
- Besik Kankia, Ilia State University, The Ohio State University
18:20-21:00 (2h40)
› Investigation of G-quadruplexes by fluorescence lifetime imaging microscopy
- Ting-Yuan Tseng, Institute of Atomic and Molecular Sciences, Academia Sinica
18:20-21:00 (2h40)
› Characterization of the interaction between cellular proteins and guanine quadruplex motifs located in the 5' UTR of mRNAs
- Jens Kurreck, Technische Universität Berlin [Berlin]
18:25-21:00 (2h35)
› G-quadruplex in the promoter region of zinc transporter protein Zip1
- Daniela Franco Bodek, Imperial College London
18:25-21:00 (2h35)
› G-quadruplexes – proteins in charge
- Václav Brázda, Institute of Biophysics of the AS CR, v.v.i.
18:25-21:00 (2h35)
› The DNA structure preferences of IFI16 protein
- Lucia Hároníková, Department of Biochemistry, Masaryk University, Institute of Biophysics of the AS CR, v.v.i.
18:25-21:00 (2h35)
› Wild-type p53 protein binding to promoter DNA quadruplexes
- Marek Petr, Institute of Biophysics of the AS CR, v.v.i.
18:25-21:00 (2h35)
› KRAS ONCOGENE REPRESSION IN COLON CANCER CELL LINES BY G-QUADRUPLEX BINDING INDOLOQUINOLINES
- Alexandra Paulo, Research Institute for Medicines, Lisbon, Portugal
18:30-21:00 (2h30)
› Occurrence of potential quadruplex-forming sequences in eukaryotic transposable elements of different age
- Matej Lexa, Faculty of Informatics [Masaryk University]
18:30-21:00 (2h30)
› System for in vivo study of DNA quadruplexes inside transposable elements
- Viktor Tokan, Department of Plant Developmental Genetics, Institue of Biophysics, Academy of Sciences CR v.v.i.
18:30-21:00 (2h30)
› The G-Quadruplex Translation Regulation of BAG-1; an mRNA Involved in Colorectal Cancer
- Rachel Jodoin, Université de Sherbrooke (CANADA)
18:30-21:00 (2h30)
› A cellular protein induces and stabilizes the HIV-1 LTR G-quadruplex conformation, a key regulatory element of viral transcription and new antiviral target
- Elena Tosoni, Department of Molecular Medicine, University of Padua - Sara Richter, Department of Molecular Medicine, University of Padua
18:35-21:00 (2h25)
› G-quadruplexes in the HIV-1 promoter
- Samir AMRANE, INSERM U869 ARNA, Bordeaux, France
18:35-21:00 (2h25)
› Kinetic studies on 5'-modified d(TGGGAG) endowed with prominent anti-HIV activity by ESI-MS
- Valeria Romanucci, Department of Chemical Sciences, University of Napoli ‘Federico II'.
18:35-21:00 (2h25)
› Methodological developments of surface plasmon resonance and application to the study of regulatory mechanisms in HCV and HIV-1.
- William Palau, ARNA Laboratory, Bordeaux, France
18:35-21:00 (2h25)
› New monomolecular G4-DNA inhibitors of HIV infection
- Anna Varizhuk, Engelhardt Institute of Molecular Biology, SRI of Physical-Chemical Medicine
18:35-21:00 (2h25)
› G-quadruplex aptamers with therapeutic applications
- Anna Avinyo, Institute for Advanced Chemistry of Catalonia
18:40-21:00 (2h20)
8:30 - 10:30 (2h)
Session 5: G4s and Replication or Helicases
Tracy Bryan
› Short loop-length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites
- Alain Nicolas, Institut Curie, Paris, France
08:30-08:50 (20min)
› Evidence that G-quadruplex levels increase during S-phase in human cells, and are elevated throughout the cell cycle in Werner and Bloom syndrome cells
- F. Brad Johnson, University of Pennsylvania, USA
08:50-09:10 (20min)
› Recognition of unique RNA structures by quadruplex helicases and their functional consequences.
- Sean McKenna, University of Manitoba, Canada
09:10-09:30 (20min)
› G4 elements and DNA replication origins: a genome-wide and functional analysis in metazoans
- Paulina Prorok, Institut de Génétique Humaine, CNRS, Montpellier, France
09:30-09:50 (20min)
› G4 motifs are necessary but not sufficient for replication initiation in Vertebrates
- Marie-Noëlle Prioleau, Institut Jacques Monod, Université Paris Diderot, Paris, France
09:50-10:10 (20min)
› Propagation of a single unresolved G quadruplex structure in proliferating tissues causes multiple genomic rearrangements and genetic heterogeneity
- Marcel Tijsterman, Leiden University Medical Center, Leiden, The Netherlands
10:10-10:30 (20min)
10:30 - 11:00 (30min)
Coffee break
11:00 - 12:20 (1h20)
Session 6: Novel G4-based Assemblies
Anh Tuan Phan
› Encapsulation and Delivery of Therapeutic Agents by Nanoparticles Formed Supramolecular G-quadruplexes
- Jose Rivera, University of Puerto Rico, Río Piedras, Puerto Rico
11:00-11:20 (20min)
› Intramolecular, Multimeric and Supramolecular G-quadruplex Assemblies
- Viktor Viglasky, Pavol Jozef Safarik University, Kosice, Slovakia
11:20-11:40 (20min)
› Stabilising i-motif DNA structures with cations and ligands
- Zoe Waller, UEA School of Pharmacy, Norwich, UK
11:40-12:00 (20min)
› The Quest for Charge Transport in single Adsorbed Long DNA-Based Molecules
- Danny Porath, Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, 91904
12:00-12:20 (20min)
12:20 - 13:10 (50min)
Poster flash presentations: Session II
Thomas C. Marsh
› DNA G-quadruplex formation: a new pathway
- Primoz Sket, EN-FIST Centre of Excellence, Slovenian NMR Centre, National Institute of Chemistry, Ljubljana, Slovenia
12:20-12:25 (05min)
› Thermodynamics and kinetics study of individual K+ binding events reveal new aspects of DNA G-quadruplex folding pathways
- Adrien Marchand, Inserm U869 ARNA, IECB, Bordeaux, France
12:25-12:30 (05min)
› Electronic Properties of Guanine Assemblies in G-quadruplex Nucleic Acids
- Christopher Lech, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
12:30-12:35 (05min)
› G-quartets and Supramolecular Structures of Guanosine-5'-monophosphates: Effect of the Ribose versus 2'-deoxyribose Residue
- Katerina Mudronova, Faculty of Mathematics and Physics, Praha/Prague, Czech Republic
12:35-12:40 (05min)
› G-quadruplex DNAzyme-modified Nucleotides for diagnostic applications
- Daniela Verga, University of Konstanz, Germany
12:40-12:45 (05min)
› Higher-Order Human Telomeric G-Quadruplex DNA Metalloenzymes Enhance Enantioselectivity in the Diels–Alder Reaction
- Yinghao Li, University of Chinese Academy of Sciences, State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, P.R. China
12:45-12:50 (05min)
› G4-hunter, a novel algorithm to predict G-quadruplex folding propensity through score computing
- Amina Bedrat, U869, Laboratoire ARNA, IECB, Bordeaux, France
12:50-12:55 (05min)
› Interaction of mutant p53 proteins with DNA quadruplexes in vitro and in cells
- Marie Brázdová, Institute of Biophysics of the AS CR, v.v.i., Brno, Czech Republic
12:55-13:00 (05min)
› Role of Nucleotide Excision Repair and Topoisomerase II proteins on pyridostatin-induced double-stranded DNA breaks
- Charlotte Dunet, Institut de pharmacologie et de biologie structurale, CNRS, Toulouse, France
13:00-13:05 (05min)
› G4s and RecQ helicases in the human malaria parasite Plasmodium falciparum
- Lynne Harris, Keele University, UK
13:05-13:10 (05min)
13:10 - 15:40 (2h30)
Lunch - Poster session II: Wed-P01 to Wed-P10 are posters that had a flash presentation, Wed-P11 to Wed-P52 are posters only
13:10 - 15:40 (2h30)
Posters (no flash): Session II
› A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands.
- Anne Bourdoncle, ARNA Laboratory, Bordeaux, France
13:10-15:40 (2h30)
› A Naphthalene Diimide Dyad as Selective Light Up Probe for G-quadruplex Sensing
- Filippo Doria, Department of Chemistry, University of Pavia
13:10-15:40 (2h30)
› Design and synthesis of a berberine dimer as a fluorescent ligand with high affinity toward G-quadruplex
- Masayuki Tera, Suntory Foundation for Life Science, Osaka, Japan
13:10-15:40 (2h30)
› Effect of low molecular weight ligands on the structural stability of G-quadruplexes
- Petra Krafčíková, University of P.J. Safarik, Košice, Slovak Republic
13:10-15:40 (2h30)
› Extended core naphtalene diimides as G-quadruplex sensors and improved anticancer compounds
- Matteo Nadai, Department of Molecular Medicine, University of Padua
13:10-15:40 (2h30)
› FRET-melting studies to assess the selectivity of G4 ligands
- Aurore De Rache, ARNA Laboratory, IECB Bordeaux, France
13:10-15:40 (2h30)
› G-quadruplex structure alteration induced by cations in relation to DNAzyme peroxidase activity
- Joanna Kosman, Laboratory of Bioanalytical Chemistry, Faculty of Chemistry, Adam Mickiewicz University
13:10-15:40 (2h30)
› Indolylmethyleneindanone based molecules specifically stabilize promoter quadruplex DNAs over telomeric and duplex DNAs
- Divesh Kumar K V, Indian Institute of Technology [Bombay] - PRADEEPKUMAR P.I., PRADEEPKUMAR P.I.
13:10-15:40 (2h30)
› Interactions of two pentanuclear lanthanide (III) metallacrowns with human telomeric DNA
- Ewa Rajczak, Adam Mickiewicz University, Faculty of Chemistry, Poland
13:10-15:40 (2h30)
› Investigation of the effect of G-quadruplex ligand on the expression and splicing of VEGF mRNA
- Taiki Saito, Graduate school of Engineering, Tokyo University of Agriculture and Technology
13:10-15:40 (2h30)
› Light induced conformational changes of the telomeric G4 DNA in complex with Zn(II) tetracarboxymethyl porphyrin
- Artemy Beniaminov, Engelhardt Institute of Molecular Biology RAS, Moscow, Russia
13:10-15:40 (2h30)
› Small Molecule Destabilisation of Intermolecular G-Quadruplexes
- Louis Chan, Department of Chemistry (Cambridge, UK)
13:10-15:40 (2h30)
› Targeting DNA quadruplexes with aromatic oligoamide foldamers
- Simon Dawson, Chimie et Biologie des Membranes et des Nanoobjets
13:10-15:40 (2h30)
› Terpyridine-platinum complexes derivatives as probes for telomere targeting
- Sophie Bombard, INSERM UMR-S 1007, Université Paris Descartes;
13:10-15:40 (2h30)
› Base Lesions in the G-tetrads and the Loops Have Varying Effects on the Folding and Stability of the Human Telomere G-quadruplex
- Helena Konvalinová, Department of Biochemistry, Faculty of Science, Masaryk University
13:15-15:40 (2h25)
› Divalent cations prefold a telomeric G-Quadruplex sequence into a nascent, parallel structural form
- Patrick Groves, University of Gdansk, Instituto de Tecnologia Química e Biológica
13:15-15:40 (2h25)
› Effective incorporation of modified nucleotides into G-quadruplex nucleic acids
- Brahim Heddi, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
13:15-15:40 (2h25)
› Gene regulation by RNA G-quadruplexes. New insights into the G-quadruplex structure at the 5'UTR of the BCL2 mRNA human proto-oncogene
- Alicia Dominguez-Martin, University of Zürich
13:15-15:40 (2h25)
› Insights from 10 µs-scale molecular dynamics simulations of human telomeric quadruplex
- Barira Islam, Central European Institute of Technology, Masaryk University
13:15-15:40 (2h25)
› Interaction between guanosine and a G-quadruplex with a vacant site
- Si Ming Pang, School of Physical and Mathematical Sciences, NTU
13:15-15:40 (2h25)
› Investigating divalent cation binding to folded G-Quadruplexes
- Malgorzata Palczewska, Department of Biomedical Chemistry, University of Gdansk, POLAND
13:15-15:40 (2h25)
› Joining of Multiple Duplex Stems at a Single Quadruplex Loop
- Kah Wai Lim, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
13:15-15:40 (2h25)
› Probing the folding dynamics of human telomeric G-quadruplex with single-molecule FRET
- Mikayel Aznauryan, Centre for DNA Nanotechnology (CDNA), Aarhus University, Interdisciplinary Nanoscience Center (iNANO), Aarhus University
13:15-15:40 (2h25)
› Structure, stability and cooperativity in guanine quadruplexes
- Celia Fonseca Guerra, VU University Amsterdam
13:15-15:40 (2h25)
› Fine-tuning of the DNA i-motif stability: lesson learnt from epigenetic regulation of telomeric DNA from plants
- Silvie Trantirkova, Central European Institute of Technology - Masaryk University
13:20-15:40 (2h20)
› Hairpin or i-Motif?
- Elise Wright, UEA School of Pharmacy, Norwich, UK
13:20-15:40 (2h20)
› Spectral characterization of i-motif enclosed in a hairpin loop for intracellular pH measurements
- Anna Dembska, Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland
13:20-15:40 (2h20)
› Study of the solution equilibria of two i-motif- and G-quadruplex-forming sequences found at the SMARCA4 gen
- Sanae Benabou, Universitat de Barcelona
13:20-15:40 (2h20)
› Discovery of a New Fluorescent Light-Up Probe Specific to Parallel G-Quadruplexes
- Shuo-Bin Chen, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou
13:25-15:40 (2h15)
› Duplex stem-loop-containing quadruplex motifs in the human genome: A combined genomic and structural study
- Vladimir Kuznetsov, Bioinformatics Institute/A*STAR
13:25-15:40 (2h15)
› Evolutionarily conserved properties of telomeric DNA
- Lukas Trantirek, Central European Institute of Technology - Masaryk University
13:25-15:40 (2h15)
› Importance of G4 structure for the activity of metazoan origins of DNA replication
- Paulina Prorok, Institut de génétique humaine - Marcel Méchali, Institut de génétique humaine
13:25-15:40 (2h15)
› Short loop length and high thermal stability determine genomic instability induced by G-quadruplex forming minisatellites
- Frédéric SAMAZAN, Dynamique de l'information génétique : bases fondamentales et cancer
13:25-15:40 (2h15)
› A dual functional G4-DNAzyme for cells antiproliferation mediated by nucleolin targeting and hydrogen peroxide trigger
- Yan Yang, Dalian Institute of Chemical Physics
13:30-15:40 (2h10)
› Molecular Diagnostics Based on Quadruplex Priming Amplification and Nicking Enzyme Activity
- Shota Gogichaishvili, Andronikashvili Institute of Physics, TSU, Tbilisi 0177, Republic of Georgia
13:30-15:40 (2h10)
› Thermodynamic and Optical properties of Quadruplex Primers for Isothermal DNA Amplification
- David Gvarjaladze, Institute of Biophysics, Ilia State University, Tbilisi 0162, Republic of Georgia
13:35-15:40 (2h05)
› Braf promoter undergoes to “non-canonical”rearrangements under nearly physiological conditions
- Maria Laura Greco, Dept. of Pharmaceutical and Pharmacological Sciences, via Marzolo 5,35131, Padova, Italy
13:40-15:40 (2h)
› Comparing p63 to other p53 family members on binding to G4
- Matej Adámik, Institute of Biophysics of the AS CR, v.v.i., Brno, CR
13:40-15:40 (2h)
› G-rich sequences within proto-oncogene KIT promoter region as targets for anticancer therapy
- claudia sissi, Department of Pharmaceutical and Pharmacological Sciences, University of Padova
13:40-15:40 (2h)
› Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation
- Stefania Millevoi, Cancer Research Center of Toulouse (CRCT)
13:40-15:40 (2h)
› The Amyloid Precursor Protein is Negatively Regulated by a 3'UTR G-quadruplex
- Ezekiel Crenshaw, Drexel University
13:40-15:40 (2h)
› Investigation of G-quadruplex-ligand interactions using NMR spectroscopy
- Julia Wirmer-Bartoschek, J.W. Goethe Universität Frankfurt, Max von Laue Str. 7, 60439 Frankfurt
13:45-15:40 (1h55)
15:40 - 18:00 (2h20)
Session 7: G4 Ligands part 2
Dipankar Sen
› Fine-tuning molecular tools for probing the G4 genome
- Marie-Paule Teulade-Fichou, Institut Curie, Orsay, France
15:40-16:00 (20min)
› Topologies selective small molecules for telemetric G-quadruplex
- Kazuo Nagasawa, Tokyo University of Agriculture and Technology, Japan
16:00-16:20 (20min)
› Fluorescent anti-tumor agents (FATAs) induced cancer cell death via the interaction of mitochondrial G-quadruplex DNA
- Ta-Chau Chang, Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
16:20-16:40 (20min)
› Topology Specific Stabilization of Promoter over Telomeric G-Quadruplex DNAs by Designer Molecules
- Pradeepkumar P.I., Indian Institute of Technology Bombay, Mumbai, India
16:40-17:00 (20min)
› Photochemistry Gives the Green Light to Tel22 Thymine Targeting
- Mauro Freccero, University of Pavia, Italy
17:00-17:20 (20min)
› Quadruplex targeting and imaging: “stay on TASQ!”
- David Monchaud, Institut de Chimie Moléculaire de l'Université de Bourgogne, Dijon, France
17:20-17:40 (20min)
› Epigenetic reprogramming with G-quadruplex ligands
- Guillaume Guilbaud, MRC Laboratory of Molecular Biology, Cambridge, UK
17:40-18:00 (20min)
19:45 - 22:30 (2h45)
Gala Dinner
8:30 - 10:30 (2h)
Session 8: Finding New G4s or G4 Interactions
Paula Bates
› DNA G-quadruplexes: moving toward a holistic view
- Antonio Randazzo, University of Naples Federico II, Naples, Italy
08:30-08:50 (20min)
› Properties, functions, and interactions of bacterial quadruplex sequences
- Jörg Hartig, University of Konstanz, Germany
08:50-09:10 (20min)
› Definition of a RNA G-quadruplexe, an unresolved question
- Jean-Pierre Perreault, Université de Sherbrooke, Canada
09:10-09:30 (20min)
› RNA Mango: A G-quadruplex for RNP complex imaging and purification
- Peter Unrau, Simon Fraser University, BC, Canada
09:30-09:50 (20min)
› High-resolution sequencing of DNA G-quadruplex secondary structures in the human genome
- Vicki Chambers, Department of Chemistry, Cambridge, UK
09:50-10:10 (20min)
› Abundant G4 structures in cells localize specifically to heterochromatin, mitotic chromosomes and some DNA fibers
- Peter Lansdorp, University of Groningen, The Netherlands
10:10-10:30 (20min)
10:30 - 11:00 (30min)
Coffee break
11:00 - 12:20 (1h20)
Session 9: Single Molecule G4 Studies
Concetta Giancola
› Single Molecule Studies on Protein-mediated G-Quadruplex Unfolding
- Hamza Balci, Department of Physics, Kent State University, USA
11:00-11:20 (20min)
› Orienting G-quadruplex polarity: the quest for the elusive RNA antiparallel quadruplex
- Oscar Mendoza, U869 ARNA (Inserm/Univ. Bordeaux)
11:20-11:40 (20min)
› Stability of c-MYC promoter G-quadruplexes in physiological potassium concentration
- Huijuan You, Mechanobiology Institute, National University of Singapore
11:40-12:00 (20min)
› Single molecule FRET analysis of telomeric G-quadruplexes
- Victoria Birkedal, Aarhus University, Denmark
12:00-12:20 (20min)
12:20 - 13:10 (50min)
Poster flash presentations: Session III
David Monchaud
› Trapping G-quadruplex DNA : from molecular tools to cellular assays
- Elodie Morel, Institut Curie, Paris, France
12:20-12:25 (05min)
› Topologically Controlled DNA and RNA G-Quadruplexes
- Laureen Bonnat, Département de Chimie Moléculaire, UJF Grenoble, France
12:25-12:30 (05min)
› G-quadruplex with (4n-1) guanines in the G-tetrad core: Formation of a G-triad·H2O complex
- Nerea Martin-Pintado, Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
12:30-12:35 (05min)
› Locking VEGF aptamer into a single G-quadruplex structure
- Maja Marušič, Slovenian NMR Center, National Institute of Chemistry, Ljubljana, Slovenia
12:35-12:40 (05min)
› Multi-modal fluorescence imaging of G-quadruplex structures in human cells.
- Aurélien Laguerre, Institut de Chimie Moléculaire, Université de Bourgogne, Dijon, France
12:40-12:45 (05min)
› Study of the impact of a highly conserved G-quadruplex motif on Xist gene expression and function during X-chromosome inactivation.
- Sarra Merzouk, European Research Institute for the Biology of Ageing University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
12:45-12:50 (05min)
› Cancer cells stimulated by DNA G-quadruplex ligands: an NMR-based metabolomics study
- Nunzia Iaccarino, University of Naples Federico II, Napoli, Italy
12:50-12:55 (05min)
› Identification and characterization of promoter-G4-associated proteins
- Silvia Götz, Department of Biochemistry, University of Wuerzburg, Germany
12:55-13:00 (05min)
› Connection of an ubiquitin ligase to genome stability at G-quadruplex structures
- Katharina Wanzek, Department of Biochemistry, University of Wuerzburg, Germany
13:00-13:05 (05min)
› Detection of cellular RNA G-quadruplexes-binding proteins
- Tatsuo Serikawa, Technische Universität Berlin, Germany
13:05-13:10 (05min)
13:10 - 15:40 (2h30)
Lunch - Poster session III: Thu-P01 to Thu-P10 are posters that had a flash presentation, Thu-P11 to Thu-P51 are posters only
13:10 - 15:40 (2h30)
Posters (no flash): Session III
› A new phenanthroline derivative for G4-Fluorescent Intercalator Displacement
- Florence Mahuteau-Betzer, Institut Curie, Orsay, France
13:10-15:40 (2h30)
› Fluorescence-Based Studies on Ligand Binding: The G-Quadruplex Perspective
- Beatrice Karg, Ernst-Moritz-Arndt-University Greifswald, Institute of Biochemistry
13:10-15:40 (2h30)
› G-Quadruplex Ligands Exhibit Differential G-tetrad Selectivity
- Daniel Le, Department of Chemistry (Cambridge, UK)
13:10-15:40 (2h30)
› Interaction of new carbazole ligand containing imidazole moiety with different forms of nucleic acids - spectroscopic study and bioactivity
- Agata Głuszyńska, Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland
13:10-15:40 (2h30)
› Interaction of phenantroline ligands with G-quadruplexes sequences
- Nassima Meriem Gueddouda, ARNA Laboratory, Bordeaux, France
13:10-15:40 (2h30)
› Natural quaternary benzo[c]phenantridine alkaloids selectively stabilize G-quadruplexes
- Raimundo Gargallo, Universitat de Barcelona
13:10-15:40 (2h30)
› The Interaction of Bis-Benzimide H33258 and Bis-Benzimide H33442 with G-quadruplexes
- Erika Demkovičova, Department of Biochemistry, Institute of Chemistry, Faculty of Sciences, Pavol Jozef Safarik University
13:10-15:40 (2h30)
› Characterization of Cationic DNA Transfection Agents Binding to Supramolecular G-DNA
- Thomas Marsh, University of St. Thomas, St. Paul, MN, USA
13:15-15:40 (2h25)
› Ion-specific self-assembly of lipophilic guanosine derivative in thin surface films
- Lucija Coga, Faculty of Mathematics and Physics [Ljubljana]
13:15-15:40 (2h25)
› SAXS analysis of anisotropic hydrogels made by G-enriched GMP quadruplexes
- Federica Carducci, Università Politecnica delle Marche
13:15-15:40 (2h25)
› Specific Effect of 5'GC-ends on the Self-assembly of Short G-rich Oligonucleotides
- Lea Spindler, Faculty of Mechanical Engineering, University of Maribor, Department of Complex Matter, Jozef Stefan Institute
13:15-15:40 (2h25)
› The Guanosine 5'- monophosphate self-assembly: effects of silver ions
- Silvia Moscatelli, Università Politecnica delle Marche
13:15-15:40 (2h25)
› Duplex Formation in Bulges of G-Quadruplexes
- Thi Quynh Ngoc Nguyen, Nanyang Technological University
13:20-15:40 (2h20)
› Equilibrium and non-equilibrium thermodynamics: yin and yang of G-quadruplex formation
- Iztok Prislan, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Vecna pot 113, 1000 Ljubljana
13:20-15:40 (2h20)
› G4s with Single-Nucleotide and Non-Nucleotide Loops: Monomolecular Parallel Folding and Aggregation
- Galina Pozmogova, SRI of Physical-Chemical Medicine, Moscow, Russia
13:20-15:40 (2h20)
› Rotation of Guanine Amino Group in G-Quadruplex Nucleic Acids
- Fernaldo Richtia Winnerdy, Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
13:20-15:40 (2h20)
› NMR study of DNA G-quadruplex formed in human KRAS oncogene promoter
- Stefaniia Ivashchenko, ARNA laboratory, Bordeaux, France
13:25-15:40 (2h15)
› Oligourea foldamer mimics in cys2his2 zinc finger peptide: towards composite protein
- Vasantha Kumar M.V., ARNA laboratory, Bordeaux, France
13:25-15:40 (2h15)
› On the Polymorphism of Telomeric G-quadruplexes Controlled by DNA Concentration and Temperature
- Peter Mojzeš, Institute of Physics, Faculty of Mathematics and Physics, Charles University in Prague [Prague]
13:25-15:40 (2h15)
› Probing G-quadruplex folding and ligand interaction in living cells using NMR spectroscopy.
- Gilmar Salgado, ARNA laboratory, Bordeaux, France
13:25-15:40 (2h15)
› Spectroscopic studies of guanine quadruplex in the regulatory region of the POU5F1 gene
- Iva Kejnovská, CEITEC - Central European Institute of Technology, Brno, Czech Republic, Institute of Biophysics of the Academy of Sciences of the Czech Rep., Brno, Czech Republic
13:25-15:40 (2h15)
› Spectroscopic study of Quadruplex-Duplex Hybrids
- Karolina Czajczynska, Polish Academy of Sciences (POLAND)
13:25-15:40 (2h15)
› Structural Characterization of a Dimer of RNA Duplexes Composed of CGG Trinucleotide Repeats: a Novel Architecture of RNA Quadruplexes
- Dorota Gudanis, Polish Academy of Sciences (POLAND)
13:25-15:40 (2h15)
› The Biological Function of G-quadruplex within WNT1 Gene Promoter and its Conformational Transition
- Margaret Kuo, Institute of Atomic and Molecular Sciences, Academia Sinica
13:25-15:40 (2h15)
› The GBA Formalism: a Rational Approach to Constructing DNA G-Quadruplexes
- Mateus Webba da Silva, Biomedical Sciences Research Institute, University of Ulster
13:25-15:40 (2h15)
› The Oxidative Damage on Telomeric G-quadruplex Structures: a Potential Protecting Role of the Loop Thymines
- Luigi Petraccone, Dep. of Chemical Sciences, Naples University Federico II
13:25-15:40 (2h15)
› The predominant formation of a left-handed G-quadruplex in NH4+
- Blaž Bakalar, Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
13:25-15:40 (2h15)
› Thermodynamic, structural and biological features of thrombin binding aptamer modified with novel UNA derivative
- Anna Pasternak, Institute of Bioorganic Chemistry, PAS, Poznan, Poland
13:25-15:40 (2h15)
› Enantioselective oxidation reaction with G-quadruplex DNA-based catalysts
- Cheng Mingpan, University of Chinese Academy of Sciences, State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
13:30-15:40 (2h10)
› Propensity of Double-Headed-Oligonucleotides to form parallel G-Quadruplex structures
- Fabrizia Nici, Universita di Napoli Federico II
13:30-15:40 (2h10)
› Structural elucidation of Binary and Ternary Complexes of Thrombin with DNA-Aptamers
- Filomena Sica, Department of Chemical Sciences, University of Naples `Federco II'
13:35-15:40 (2h05)
› G4RNA: an RNA G-quadruplex database
- Jean-Michel Garant, Université de Sherbrooke
13:40-15:40 (2h)
› Identification of proteins binding to the parallel arrangement of telomeric G-quadruplex DNA
- Jussara Amato, University of Naples Federico II [Naples]
13:40-15:40 (2h)
› Isolation of G-quadruplexes by pull-down strategy using telomestatin derivatives
- Shadi Sedghi Masoud, Tokyo University of Agriculture and Technology
13:40-15:40 (2h)
› Nucleic Acid Detection and Quantification Methods based on DNA Quadruplexes
- Levan Lomidze, Institute of Biophysics, Ilia State University
13:40-15:40 (2h)
› A triarylpyridine G-quadruplex ligand promotes autophagy and cell death in HeLa cancer cells
- Paul Bensadoun & Mojgan Djavaheri-Mergny, INSERM U916 VINCO & Univ. Bordeaux
13:45-15:40 (1h55)
› G-quadruplexes in pathogenic microbes: a common route to virulence control?
- Catherine Merrick, Keele University, UK
13:45-15:40 (1h55)
› The RNA binding protein hnRNP A1 regulates Ron mRNA translation and breast cancer metastasis
- Anne Cammas, Centre de Recherches en Cancérologie de Toulouse
13:45-15:40 (1h55)
› G-quadruplexes, G4 resolvases and posttrancriptionnal regulation
- Angelique Pipier, Institut de pharmacologie et de biologie structurale
13:50-15:40 (1h50)
› Processing of double-R-loops in (CAG)/(CTG) and C9orf72 (GGGGCC)/(GGCCCC) repeats causes instability
- Mila Mirceta, Department of Genetics, The Hospital for Sick Children, Toronto
13:50-15:40 (1h50)
› The nuclear Pfh1 DNA helicase efficiently unwinds G-quadruplex DNA
- Nasim Sabouri, Umea University (SWEDEN)
13:50-15:40 (1h50)
15:40 - 18:10 (2h30)
Session 10: The Relation of G4 to Disease
Jonathan B. Chaires
› Unusual RNA / DNA structures formed by disease-associated C9orf72 repeats (GGGGCC)n/(GGCCCC)n: Roles in mutagenesis and pathogenesis
- Christopher Pearson, The Hospital for Sick Children, Toronto, Canada
15:40-16:00 (20min)
› T7 RNA Polymerase Controls a Strand-Biased Formation of G-Quadruplex in Transcription of DNA Duplex
- Zheng Tan, Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China
16:00-16:20 (20min)
› Translation Suppression by G-quadruplex
- Naoki Sugimoto, Konan University, Kobe, Japan
16:20-16:40 (20min)
› DNA Damage Changes the Duplex-Quadruplex Equilibrium in Promoters and Impacts Transcription
- Aaron Fleming, University of Utah, USA
16:40-17:00 (20min)
› Resistance to 360A induces telomere alteration and genome-wide quadruplex reprogramming of gene transcription
- Jean-François Riou, Laboratoire Structure et Instabilité des Génomes, Museum National d'Histoire Naturelle, Paris, France
17:00-17:20 (20min)
› G-quadruplexes in the herpes simplex virus-1: presence, function and targeting in vitro and in infected cells
- Sara Richter, Department of Molecular Medicine, University of Padua, Italy
17:20-17:40 (20min)
› G-quadruplex Genomic Targets for Transcriptional Regulation
- Nancy Maizels, University of Washington, Seattle, WA, USA
17:40-18:10 (30min)
18:10 - 18:20 (10min)
Closing - Awards ceremony
Valérie Gabelica
